1urc Summary


Cyclin A binding groove inhibitor Ace-Arg-Lys-Leu-Phe-Gly

The structure was published by Andrews, M., Mcinnes, C., Kontopidis, G., et al., Cowan, A., Plater, A., and Fischer, P., in 2004 in a paper entitled "Design, Synthesis, Biological Activity and Structural Analysis of Cyclic Peptide Inhibitors Targeting the Substrate Recruitment Site of Cyclin-Dependent Kinase Complexes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, and PEPTIDE INHIBITOR.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
B CYCLIN A2 P20248 (173-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 99%
D CYCLIN A2 P20248 (173-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 99%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (173 - 432) CYCLIN A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P24941) protein phosphorylationsearch positive regulation of transcription, DNA-templatedsearch G2/M transition of mitotic cell cyclesearch meiotic nuclear divisionsearch cell cyclesearch DNA replicationsearch histone phosphorylationsearch blood coagulationsearch mitotic cell cyclesearch cellular response to nitric oxidesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch potassium ion transportsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch positive regulation of cell proliferationsearch G1/S transition of mitotic cell cyclesearch Ras protein signal transductionsearch mitotic G1 DNA damage checkpointsearch DNA repairsearch positive regulation of DNA-dependent DNA replication initiationsearch meiotic cell cyclesearch mitotic nuclear divisionsearch cellular response to DNA damage stimulussearch regulation of gene silencingsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch centrosome duplicationsearch phosphorylationsearch cell divisionsearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch metal ion bindingsearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch transferase activitysearch nucleotide bindingsearch kinase activitysearch cyclin bindingsearch histone kinase activitysearch cytoplasmsearch microtubule organizing centersearch nucleoplasmsearch Y chromosomesearch endosomesearch cytosolsearch Cajal bodysearch cytoskeletonsearch nucleussearch X chromosomesearch transcription factor complexsearch condensed chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch chromosome, telomeric regionsearch centrosomesearch
B, D (P20248) regulation of G2/M transition of mitotic cell cyclesearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of cell cyclesearch protein kinase bindingsearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/F/Osearch Cyclin A, chordatessearch