1uqt Summary

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TREHALOSE-6-PHOSPHATE FROM E. COLI BOUND WITH UDP-2-FLUORO GLUCOSE.

The structure was published by Gibson, R.P., Tarling, C.A., Roberts, S., Withers, S.G., and Davies, G.J., in 2004 in a paper entitled "The Donor Subsite of Trehalose-6-Phosphate Synthase: Binary Complexes with Udp-Glucose and Udp-2-Deoxy-2-Fluoro-Glucose at 2 A Resolution" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of ALPHA, ALPHA-TREHALOSE-PHOSPHATE SYNTHASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ALPHA, ALPHA-TREHALOSE-PHOSPHATE SYNTHASE P31677 (2-474) (OTSA_ECOLI)search Escherichia coli K-12search 96% 482 93%
B ALPHA, ALPHA-TREHALOSE-PHOSPHATE SYNTHASE P31677 (2-474) (OTSA_ECOLI)search Escherichia coli K-12search 96% 482 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P31677 (2 - 474) ALPHA, ALPHA-TREHALOSE-PHOSPHATE SYNTHASE Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P31677) Trehalose-6-phosphate synthase, OtsAsearch Glycogen Phosphorylase B;search PF00982: Glycosyltransferase family 20search

Chain ID Biological process (GO) Molecular function (GO)
A, B (P31677) cellular response to DNA damage stimulussearch response to osmotic stresssearch response to stresssearch trehalose biosynthetic processsearch trehalose metabolism in response to cold stresssearch alpha,alpha-trehalose-phosphate synthase (UDP-forming) activitysearch transferase activity, transferring glycosyl groupssearch transferase activitysearch

Chain InterPro annotation
A, B Glycosyl transferase, family 20search Alpha,alpha-trehalose-phosphate synthasesearch