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CRYSTAL STRUCTURE OF THE HUMAN LIVER X RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH A SYNTHETIC AGONIST

The structure was published by Hoerer, S., Schmid, A., Heckel, A., Budzinski, R.M., and Nar, H., in 2003 in a paper entitled "Crystal Structure of the Human Liver X Receptor Beta Ligand-Binding Domain in Complex with a Synthetic Agonist" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of OXYSTEROLS RECEPTOR LXR-BETA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A OXYSTEROLS RECEPTOR LXR-BETA P55055 (208-460) (NR1H2_HUMAN)search Homo sapienssearch < 90% 257 90%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P55055 (208 - 460) OXYSTEROLS RECEPTOR LXR-BETA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P55055) nucleussearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch Liver X receptorsearch