› 1upr

X-ray diffraction
2.27Å resolution

Crystal structure of the PEPP1 pleckstrin homology domain in complex with Inositol 1,3,4,5-tetrakisphosphate

Released:
DOI: 10.2210/pdb1upr/pdb
PDB entry 1upr coloured by chain, front view.
PDB entry 1upr coloured by chain, side view.
PDB entry 1upr coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Milburn CC, Komander D, Deak M, Alessi DR, Van Aalten DMF

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190614 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pleckstrin homology domain-containing family A member 4 Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 14.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9H4M7 (Residues: 45-167; Coverage: 16%)
Gene names: PEPP1, PLEKHA4
Sequence domains: PH domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

1 bound ligand:
Ligand 4IP 1 x 4IP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: P4212
Unit cell:
a: 92.577Å b: 92.577Å c: 35.571Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.237 0.276
Expression system: Escherichia coli BL21

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