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Structure Based Engineering of Internal Molecular Surfaces Of Four Helix Bundles

X-ray diffraction
2.2Å resolution
PDB entry 1unw coloured by chain, front view.
PDB entry 1unw coloured by chain, side view.
PDB entry 1unw coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: General control transcription factor GCN4
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Multimeric state: homo tetramer
Accessible surface area: 6917.54 Å2
Buried surface area: 6814.29 Å2
Dissociation area: 3,407.14 Å2
Dissociation energy (ΔGdiss): 43.8 kcal/mol
Dissociation entropy (TΔSdiss): 28.89 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-136532

Macromolecules

General control transcription factor GCN4
Chains: A, B
Length: 34 amino acids
Theoretical weight: 4.02 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Not provided
UniProt:
  • Canonical: P03069 (Residues: 249-281; Coverage: 12%)
Gene names: AAS101, AAS3, ARG9, GCN4, YEL009C
Pfam: Basic region leucine zipper
InterPro: Basic-leucine zipper domain superfamily
SCOP: Leucine zipper domain
General control transcription factor GCN4 in PDB entry 1unw, assembly 1, front view.
General control transcription factor GCN4 in PDB entry 1unw, assembly 1, side view.
General control transcription factor GCN4 in PDB entry 1unw, assembly 1, top view.
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