1unh Summary

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STRUCTURAL MECHANISM FOR THE INHIBITION OF CDK5-P25 BY ROSCOVITINE, ALOISINE AND INDIRUBIN.

The structure was published by Mapelli, M., Massimilinao, L., Crovace, C., et al., Tsai, L.-H., Meijer, L., and Musacchio, A., in 2005 in a paper entitled "Mechanism of Cdk5/P25 Binding by Cdk Inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.35 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CYCLIN-DEPENDENT KINASE 5 and CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLIN-DEPENDENT KINASE 5 Q00535 (1-292) (CDK5_HUMAN)search Homo sapienssearch 100% 292 94%
B CYCLIN-DEPENDENT KINASE 5 Q00535 (1-292) (CDK5_HUMAN)search Homo sapienssearch 100% 292 94%
D CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 Q15078 (100-307) (CD5R1_HUMAN)search Homo sapienssearch < 90% 208 71%
E CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 Q15078 (100-307) (CD5R1_HUMAN)search Homo sapienssearch < 90% 208 71%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q00535 (1 - 292) CYCLIN-DEPENDENT KINASE 5 Homo sapiens
Q15078 (100 - 307) CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q00535) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
D, E Cyclinsearch Cyclin A; domain 1search Cyclin-dependent kinase 5 activator proteinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (Q00535) protein kinase activitysearch protein bindingsearch ATP bindingsearch tau-protein kinase activitysearch protein serine/threonine kinase activitysearch p53 bindingsearch ErbB-3 class receptor bindingsearch nucleotide bindingsearch ErbB-2 class receptor bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch transferase activitysearch acetylcholine receptor activator activitysearch ephrin receptor bindingsearch lamellipodiumsearch axonsearch postsynaptic densitysearch plasma membranesearch membranesearch cytoskeletonsearch neuronal cell bodysearch cell projectionsearch filopodiumsearch cytosolsearch cytoplasmsearch neuromuscular junctionsearch perikaryonsearch growth conesearch postsynaptic membranesearch dendritesearch synapsesearch cell junctionsearch nucleussearch cyclin-dependent protein kinase 5 holoenzyme complexsearch neuron migrationsearch sensory perception of painsearch exocytosissearch positive regulation of receptor activitysearch positive regulation of protein kinase activitysearch motor neuron axon guidancesearch phosphorylationsearch regulation of cell cycle arrestsearch neuron apoptotic processsearch telencephalon developmentsearch cerebellum developmentsearch regulation of synaptic plasticitysearch negative regulation of cell cyclesearch peptidyl-serine phosphorylationsearch peptidyl-threonine phosphorylationsearch visual learningsearch embryo developmentsearch positive regulation of calcium ion-dependent exocytosissearch hippocampus developmentsearch cell migrationsearch serine phosphorylation of STAT3 proteinsearch cell divisionsearch regulation of excitatory postsynaptic membrane potentialsearch positive regulation of protein targeting to membranesearch axon guidancesearch regulation of cell migrationsearch neuron projection developmentsearch skeletal muscle tissue developmentsearch negative regulation of neuron deathsearch regulation of dendritic spine morphogenesissearch synaptic vesicle endocytosissearch synapse assemblysearch associative learningsearch protein phosphorylationsearch oligodendrocyte differentiationsearch axon extensionsearch axonogenesissearch receptor catabolic processsearch rhythmic processsearch cell deathsearch cerebral cortex developmentsearch receptor clusteringsearch negative regulation of synaptic plasticitysearch negative regulation of proteolysissearch positive regulation of actin cytoskeleton reorganizationsearch positive regulation of neuron apoptotic processsearch synaptic vesicle exocytosissearch apoptotic processsearch cell proliferationsearch positive regulation of protein bindingsearch forebrain developmentsearch response to woundingsearch protein autophosphorylationsearch regulation of apoptotic processsearch layer formation in cerebral cortexsearch cortical actin cytoskeleton organizationsearch cell-matrix adhesionsearch negative regulation of protein ubiquitinationsearch nucleocytoplasmic transportsearch neuron differentiationsearch negative regulation of axon extensionsearch regulated secretory pathwaysearch blood coagulationsearch synaptic transmissionsearch negative regulation of protein export from nucleussearch Schwann cell developmentsearch calcium ion importsearch cell cyclesearch central nervous system neuron developmentsearch negative regulation of transcription, DNA-templatedsearch nervous system developmentsearch synaptic transmission, glutamatergicsearch neuron projection morphogenesissearch intracellular protein transportsearch protein localization to synapsesearch behavioral response to cocainesearch dendrite morphogenesissearch corpus callosum developmentsearch cerebellar cortex developmentsearch synaptic transmission, dopaminergicsearch cerebellar cortex formationsearch regulation of postsynaptic membrane potentialsearch response to cocainesearch
D, E (Q15078) cyclin-dependent protein kinase 5 activator activitysearch cyclin-dependent protein kinase 5 holoenzyme complexsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
D, E Cyclin-dependent kinase 5 activatorsearch Cyclin-likesearch