1ung Summary

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STRUCTURAL MECHANISM FOR THE INHIBITION OF CDK5-P25 BY ROSCOVITINE, ALOISINE AND INDIRUBIN.

The structure was published by Mapelli, M., Massimilinao, L., Crovace, C., et al., Tsai, L.-H., Meijer, L., and Musacchio, A., in 2005 in a paper entitled "Mechanism of Cdk5/P25 Binding by Cdk Inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 5 and CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 5 Q00535 (1-292) (CDK5_HUMAN)search Homo sapienssearch 100% 292 98%
B CELL DIVISION PROTEIN KINASE 5 Q00535 (1-292) (CDK5_HUMAN)search Homo sapienssearch 100% 292 98%
D CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 Q15078 (100-307) (CD5R1_HUMAN)search Homo sapienssearch < 90% 208 72%
E CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 Q15078 (100-307) (CD5R1_HUMAN)search Homo sapienssearch < 90% 208 72%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q00535 (1 - 292) CELL DIVISION PROTEIN KINASE 5 Homo sapiens
Q15078 (100 - 307) CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q00535) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
D, E Cyclinsearch Cyclin A; domain 1search Cyclin-dependent kinase 5 activator proteinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q00535) protein kinase activitysearch protein serine/threonine kinase activitysearch protein bindingsearch kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch acetylcholine receptor activator activitysearch ErbB-2 class receptor bindingsearch tau-protein kinase activitysearch nucleotide bindingsearch transferase activitysearch ErbB-3 class receptor bindingsearch p53 bindingsearch ephrin receptor bindingsearch neuron differentiationsearch synaptic vesicle exocytosissearch axonogenesissearch synaptic vesicle endocytosissearch positive regulation of receptor activitysearch associative learningsearch cell migrationsearch cerebellar cortex formationsearch positive regulation of actin cytoskeleton reorganizationsearch serine phosphorylation of STAT3 proteinsearch neuron apoptotic processsearch visual learningsearch phosphorylationsearch apoptotic processsearch central nervous system neuron developmentsearch cerebellar cortex developmentsearch regulated secretory pathwaysearch negative regulation of proteolysissearch positive regulation of neuron apoptotic processsearch synaptic transmission, glutamatergicsearch regulation of synaptic plasticitysearch synaptic transmissionsearch negative regulation of axon extensionsearch protein phosphorylationsearch hippocampus developmentsearch neuron migrationsearch synapse assemblysearch nucleocytoplasmic transportsearch axon guidancesearch cell divisionsearch regulation of cell migrationsearch regulation of dendritic spine morphogenesissearch positive regulation of protein bindingsearch cell-matrix adhesionsearch negative regulation of protein ubiquitinationsearch dendrite morphogenesissearch negative regulation of transcription, DNA-templatedsearch cell proliferationsearch response to woundingsearch corpus callosum developmentsearch positive regulation of protein targeting to membranesearch negative regulation of neuron deathsearch skeletal muscle tissue developmentsearch cell deathsearch axon extensionsearch Schwann cell developmentsearch rhythmic processsearch positive regulation of calcium ion-dependent exocytosissearch embryo developmentsearch cerebellum developmentsearch regulation of cell cycle arrestsearch layer formation in cerebral cortexsearch nervous system developmentsearch neuron projection morphogenesissearch behavioral response to cocainesearch response to cocainesearch peptidyl-serine phosphorylationsearch telencephalon developmentsearch negative regulation of cell cyclesearch regulation of apoptotic processsearch forebrain developmentsearch protein localization to synapsesearch peptidyl-threonine phosphorylationsearch negative regulation of synaptic plasticitysearch exocytosissearch motor neuron axon guidancesearch cell cyclesearch cortical actin cytoskeleton organizationsearch receptor clusteringsearch intracellular protein transportsearch calcium ion importsearch oligodendrocyte differentiationsearch regulation of excitatory postsynaptic membrane potentialsearch synaptic transmission, dopaminergicsearch protein autophosphorylationsearch blood coagulationsearch neuron projection developmentsearch cerebral cortex developmentsearch positive regulation of protein kinase activitysearch sensory perception of painsearch negative regulation of protein export from nucleussearch receptor catabolic processsearch regulation of postsynaptic membrane potentialsearch cytoskeletonsearch nucleussearch axonsearch dendritesearch growth conesearch filopodiumsearch cell junctionsearch lamellipodiumsearch postsynaptic densitysearch membranesearch cytosolsearch cyclin-dependent protein kinase 5 holoenzyme complexsearch plasma membranesearch cytoplasmsearch neuronal cell bodysearch neuromuscular junctionsearch postsynaptic membranesearch perikaryonsearch synapsesearch cell projectionsearch
D, E (Q15078) cyclin-dependent protein kinase 5 activator activitysearch cyclin-dependent protein kinase 5 holoenzyme complexsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
D, E Cyclin-dependent kinase 5 activatorsearch Cyclin-likesearch