1ung Summary

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STRUCTURAL MECHANISM FOR THE INHIBITION OF CDK5-P25 BY ROSCOVITINE, ALOISINE AND INDIRUBIN.

The structure was published by Mapelli, M., Massimilinao, L., Crovace, C., et al., Tsai, L.-H., Meijer, L., and Musacchio, A., in 2005 in a paper entitled "Mechanism of Cdk5/P25 Binding by Cdk Inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 5 and CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 5 Q00535 (1-292) (CDK5_HUMAN)search Homo sapienssearch 100% 292 98%
B CELL DIVISION PROTEIN KINASE 5 Q00535 (1-292) (CDK5_HUMAN)search Homo sapienssearch 100% 292 98%
D CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 Q15078 (100-307) (CD5R1_HUMAN)search Homo sapienssearch < 90% 208 72%
E CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 Q15078 (100-307) (CD5R1_HUMAN)search Homo sapienssearch < 90% 208 72%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q00535 (1 - 292) CELL DIVISION PROTEIN KINASE 5 Homo sapiens
Q15078 (100 - 307) CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q00535) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
D, E Cyclinsearch Cyclin A; domain 1search Cyclin-dependent kinase 5 activator proteinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (Q00535) cytoplasmsearch cytosolsearch axonsearch postsynaptic densitysearch dendritesearch neuronal cell bodysearch perikaryonsearch growth conesearch neuromuscular junctionsearch nucleussearch plasma membranesearch lamellipodiumsearch membranesearch postsynaptic membranesearch cyclin-dependent protein kinase 5 holoenzyme complexsearch filopodiumsearch cell junctionsearch cytoskeletonsearch cell projectionsearch synapsesearch protein serine/threonine kinase activitysearch tau-protein kinase activitysearch p53 bindingsearch protein bindingsearch ATP bindingsearch ErbB-2 class receptor bindingsearch ErbB-3 class receptor bindingsearch kinase activitysearch cytoskeletal protein bindingsearch acetylcholine receptor activator activitysearch protein kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch nucleotide bindingsearch transferase activitysearch ephrin receptor bindingsearch transferase activity, transferring phosphorus-containing groupssearch regulation of dendritic spine morphogenesissearch negative regulation of protein ubiquitinationsearch intracellular protein transportsearch regulation of synaptic plasticitysearch rhythmic processsearch regulation of cell migrationsearch neuron migrationsearch axon guidancesearch nervous system developmentsearch positive regulation of protein kinase activitysearch phosphorylationsearch cortical actin cytoskeleton organizationsearch positive regulation of receptor activitysearch axon extensionsearch motor neuron axon guidancesearch skeletal muscle tissue developmentsearch negative regulation of neuron deathsearch behavioral response to cocainesearch negative regulation of transcription, DNA-templatedsearch cell proliferationsearch central nervous system neuron developmentsearch response to woundingsearch cell migrationsearch synaptic transmission, glutamatergicsearch positive regulation of calcium ion-dependent exocytosissearch negative regulation of synaptic plasticitysearch regulation of postsynaptic membrane potentialsearch regulation of apoptotic processsearch synapse assemblysearch protein phosphorylationsearch regulated secretory pathwaysearch negative regulation of axon extensionsearch peptidyl-serine phosphorylationsearch regulation of cell cycle arrestsearch cerebellar cortex developmentsearch positive regulation of protein bindingsearch serine phosphorylation of STAT3 proteinsearch axonogenesissearch receptor clusteringsearch apoptotic processsearch telencephalon developmentsearch associative learningsearch calcium ion importsearch visual learningsearch peptidyl-threonine phosphorylationsearch layer formation in cerebral cortexsearch cell cyclesearch neuron projection developmentsearch neuron apoptotic processsearch negative regulation of protein export from nucleussearch embryo developmentsearch dendrite morphogenesissearch cerebellum developmentsearch blood coagulationsearch sensory perception of painsearch cerebellar cortex formationsearch neuron projection morphogenesissearch regulation of excitatory postsynaptic membrane potentialsearch hippocampus developmentsearch synaptic vesicle endocytosissearch exocytosissearch negative regulation of cell cyclesearch regulation of synaptic vesicle recyclingsearch cerebral cortex developmentsearch oligodendrocyte differentiationsearch forebrain developmentsearch cell-matrix adhesionsearch neuron differentiationsearch Schwann cell developmentsearch positive regulation of protein targeting to membranesearch cell divisionsearch positive regulation of neuron apoptotic processsearch synaptic vesicle exocytosissearch nucleocytoplasmic transportsearch synaptic transmission, dopaminergicsearch response to cocainesearch corpus callosum developmentsearch synaptic transmissionsearch protein localization to synapsesearch receptor catabolic processsearch positive regulation of actin cytoskeleton reorganizationsearch negative regulation of proteolysissearch protein autophosphorylationsearch
D, E (Q15078) cyclin-dependent protein kinase 5 holoenzyme complexsearch cyclin-dependent protein kinase 5 activator activitysearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
D, E Cyclin-dependent kinase 5 activatorsearch Cyclin-likesearch