1ung Summary

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STRUCTURAL MECHANISM FOR THE INHIBITION OF CDK5-P25 BY ROSCOVITINE, ALOISINE AND INDIRUBIN.

The structure was published by Mapelli, M., Massimilinao, L., Crovace, C., et al., Tsai, L.-H., Meijer, L., and Musacchio, A., in 2005 in a paper entitled "Mechanism of Cdk5/P25 Binding by Cdk Inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 5 and CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 5 Q00535 (1-292) (CDK5_HUMAN)search Homo sapienssearch 100% 292 98%
B CELL DIVISION PROTEIN KINASE 5 Q00535 (1-292) (CDK5_HUMAN)search Homo sapienssearch 100% 292 98%
D CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 Q15078 (100-307) (CD5R1_HUMAN)search Homo sapienssearch < 90% 208 72%
E CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 Q15078 (100-307) (CD5R1_HUMAN)search Homo sapienssearch < 90% 208 72%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q00535 (1 - 292) CELL DIVISION PROTEIN KINASE 5 Homo sapiens
Q15078 (100 - 307) CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q00535) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
D, E Cyclinsearch Cyclin A; domain 1search Cyclin-dependent kinase 5 activator proteinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q00535) ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch tau-protein kinase activitysearch ErbB-2 class receptor bindingsearch p53 bindingsearch acetylcholine receptor activator activitysearch kinase activitysearch ErbB-3 class receptor bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch ephrin receptor bindingsearch transferase activitysearch nucleotide bindingsearch protein phosphorylationsearch synaptic transmission, dopaminergicsearch peptidyl-threonine phosphorylationsearch response to woundingsearch neuron projection developmentsearch response to cocainesearch neuron migrationsearch cell divisionsearch axon guidancesearch cerebral cortex developmentsearch regulation of dendritic spine morphogenesissearch regulation of synaptic plasticitysearch negative regulation of protein ubiquitinationsearch regulated secretory pathwaysearch dendrite morphogenesissearch peptidyl-serine phosphorylationsearch cerebellar cortex formationsearch cell cyclesearch negative regulation of transcription, DNA-templatedsearch cell proliferationsearch embryo developmentsearch axon extensionsearch forebrain developmentsearch negative regulation of neuron deathsearch telencephalon developmentsearch hippocampus developmentsearch regulation of excitatory postsynaptic membrane potentialsearch positive regulation of protein kinase activitysearch synaptic vesicle endocytosissearch nucleocytoplasmic transportsearch synaptic transmission, glutamatergicsearch regulation of apoptotic processsearch synapse assemblysearch cortical actin cytoskeleton organizationsearch cell-matrix adhesionsearch nervous system developmentsearch layer formation in cerebral cortexsearch receptor clusteringsearch neuron projection morphogenesissearch regulation of cell cycle arrestsearch skeletal muscle tissue developmentsearch visual learningsearch negative regulation of axon extensionsearch receptor catabolic processsearch behavioral response to cocainesearch cell migrationsearch cerebellar cortex developmentsearch phosphorylationsearch motor neuron axon guidancesearch negative regulation of protein export from nucleussearch sensory perception of painsearch apoptotic processsearch regulation of postsynaptic membrane potentialsearch cell deathsearch rhythmic processsearch intracellular protein transportsearch calcium ion importsearch positive regulation of neuron apoptotic processsearch blood coagulationsearch central nervous system neuron developmentsearch negative regulation of synaptic plasticitysearch serine phosphorylation of STAT3 proteinsearch neuron differentiationsearch synaptic vesicle exocytosissearch neuron apoptotic processsearch regulation of cell migrationsearch positive regulation of calcium ion-dependent exocytosissearch oligodendrocyte differentiationsearch corpus callosum developmentsearch axonogenesissearch positive regulation of protein targeting to membranesearch exocytosissearch negative regulation of cell cyclesearch cerebellum developmentsearch Schwann cell developmentsearch positive regulation of actin cytoskeleton reorganizationsearch protein localization to synapsesearch synaptic vesicle recyclingsearch synaptic transmissionsearch associative learningsearch negative regulation of proteolysissearch positive regulation of protein bindingsearch protein autophosphorylationsearch positive regulation of receptor activitysearch cytoplasmsearch cytosolsearch nucleussearch dendritesearch axonsearch membranesearch neuronal cell bodysearch neuromuscular junctionsearch growth conesearch cyclin-dependent protein kinase 5 holoenzyme complexsearch lamellipodiumsearch postsynaptic densitysearch filopodiumsearch cell junctionsearch synapsesearch postsynaptic membranesearch cell projectionsearch cytoskeletonsearch plasma membranesearch
D, E (Q15078) cyclin-dependent protein kinase 5 activator activitysearch cyclin-dependent protein kinase 5 holoenzyme complexsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
D, E Cyclin-dependent kinase 5 activatorsearch Cyclin-likesearch