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Deacetoxycephalosporin C synthase complexed with 2-oxoglutarate and ampicillin

X-ray diffraction
1.5Å resolution
PDB entry 1unb coloured by chain, front view.
PDB entry 1unb coloured by chain, side view.
PDB entry 1unb coloured by chain, top view.
Source organism: Streptomyces clavuligerus
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Deacetoxycephalosporin C synthase
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Multimeric state: homo trimer
Accessible surface area: 31128.08 Å2
Buried surface area: 11496.82 Å2
Dissociation area: 3,998.32 Å2
Dissociation energy (ΔGdiss): 21.79 kcal/mol
Dissociation entropy (TΔSdiss): 27.84 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-148404

Macromolecules

Deacetoxycephalosporin C synthase
Chain: A
Length: 311 amino acids
Theoretical weight: 34.59 KDa
Source organism: Streptomyces clavuligerus
Expression system: Escherichia coli
UniProt:
  • Canonical: P18548 (Residues: 1-311; Coverage: 100%)
Gene name: cefE
Pfam: 2OG-Fe(II) oxygenase superfamily
InterPro:
CATH: B-lactam Antibiotic, Isopenicillin N Synthase; Chain
SCOP: Penicillin synthase-like
Deacetoxycephalosporin C synthase in PDB entry 1unb, assembly 1, front view.
Deacetoxycephalosporin C synthase in PDB entry 1unb, assembly 1, side view.
Deacetoxycephalosporin C synthase in PDB entry 1unb, assembly 1, top view.
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