1uki Summary

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Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125

The structure was published by Heo, Y.-S., Kim, S.K., Seo, C.I., et al., Cho, J.M., Lee, T.G., and Yang, C.-H., in 2004 in a paper entitled "Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely mitogen-activated protein kinase 8 isoform 4 and 11-mer peptide from C-jun-amino-terminal kinase interacting protein 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A mitogen-activated protein kinase 8 isoform 4 P45983 (1-363) (MK08_HUMAN)search Homo sapienssearch < 90% 369 88%
B 11-mer peptide from C-jun-amino-terminal kinase interacting protein 1 Q9WVI9 (153-163) (JIP1_MOUSE)search Mus musculussearch < 90% 11 90%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P45983 (1 - 363) mitogen-activated protein kinase 8 isoform 4 Homo sapiens
Q9WVI9 (153 - 163) 11-mer peptide from C-jun-amino-terminal kinase interacting protein 1

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch
B

Chain ID Biological process (GO) Molecular function (GO)
A (P45983) protein phosphorylationsearch MAP kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, JNKsearch Protein kinase-like domainsearch
B