1ui8 Summary


Site-directed mutagenesis of His592 involved in binding of copper ion in Arthrobacter globiformis amine oxidase

The structure was published by Matsunami, H., Okajima, T., Hirota, S., et al., Hori, H., Kuroda, S., and Tanizawa, K., in 2004 in a paper entitled "Chemical rescue of a site-specific mutant of bacterial copper amine oxidase for generation of the topa quinone cofactor" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Phenylethylamine oxidase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Phenylethylamine oxidase P46881 (1-638) (PAOX_ARTGO)search Arthrobacter globiformissearch 97% 638 97%
B Phenylethylamine oxidase P46881 (1-638) (PAOX_ARTGO)search Arthrobacter globiformissearch 97% 638 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P46881 (1 - 638) Phenylethylamine oxidase Arthrobacter globiformis

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P46881) Amine oxidase catalytic domainsearch, Amine oxidase N-terminal regionsearch Nuclear Transport Factor 2; Chain: A,search, Copper amine oxidase, Domain 3search PF01179: Copper amine oxidase, enzyme domainsearch, PF02728: Copper amine oxidase, N3 domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P46881) primary amine oxidase activitysearch quinone bindingsearch copper ion bindingsearch aliphatic-amine oxidase activitysearch tryptamine:oxygen oxidoreductase (deaminating) activitysearch aminoacetone:oxygen oxidoreductase(deaminating) activitysearch phenethylamine:oxygen oxidoreductase (deaminating) activitysearch oxidoreductase activitysearch metal ion bindingsearch amine metabolic processsearch oxidation-reduction processsearch

Chain InterPro annotation
A, B Copper amine oxidasesearch Copper amine oxidase, C-terminalsearch Copper amine oxidase, N2/N3-terminalsearch Copper amine oxidase, N3-terminalsearch Copper amine oxidase, N-terminalsearch