1uhl Summary

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Crystal structure of the LXRalfa-RXRbeta LBD heterodimer

The structure was published by Svensson, S., Ostberg, T., Jacobsson, M., et al., Zachrisson, K., Ogg, D., and Jendeberg, L., in 2003 in a paper entitled "Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Retinoic acid receptor RXR-beta, Oxysterols receptor LXR-alpha, and 10-mer peptide from Nuclear receptor coactivator 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Retinoic acid receptor RXR-beta P28702 (298-533) (RXRB_HUMAN)search Homo sapienssearch < 90% 236 90%
B Oxysterols receptor LXR-alpha Q13133 (207-447) (NR1H3_HUMAN)search Homo sapienssearch < 90% 242 90%
C 10-mer peptide from Nuclear receptor coactivator 2 Q15596 (687-696) (NCOA2_HUMAN)search Homo sapienssearch < 90% 10 100%
D 10-mer peptide from Nuclear receptor coactivator 2 Q15596 (687-696) (NCOA2_HUMAN)search Homo sapienssearch < 90% 10 100%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P28702 (298 - 533) Retinoic acid receptor RXR-beta Homo sapiens
Q13133 (207 - 447) Oxysterols receptor LXR-alpha Homo sapiens
Q15596 (687 - 696) 10-mer peptide from Nuclear receptor coactivator 2

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
C, D Steroid receptor coactivatorsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P28702) nucleussearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch zinc ion bindingsearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch
B (Q13133) nucleussearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch DNA bindingsearch steroid hormone mediated signaling pathwaysearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A Retinoid X receptor/HNF4search Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch Liver X receptorsearch
C, D