1uge Summary

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HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY LEU (A65L)

The structure was published by Scolnick, L.R. and Christianson, D.W., in 1996 in a paper entitled "X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 258 residues which is 99% of the natural sequence. Out of 258 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (3-260) (CAH2_HUMAN)search Homo sapienssearch 98% 258 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (3 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) one-carbon metabolic processsearch regulation of anion transportsearch bicarbonate transportsearch small molecule metabolic processsearch kidney developmentsearch odontogenesis of dentin-containing toothsearch response to pHsearch positive regulation of osteoclast differentiationsearch secretionsearch positive regulation of dipeptide transmembrane transportsearch carbon dioxide transportsearch angiotensin-activated signaling pathwaysearch positive regulation of bone resorptionsearch regulation of intracellular pHsearch positive regulation of cellular pH reductionsearch response to zinc ionsearch response to steroid hormonesearch response to estrogensearch response to organic substancesearch morphogenesis of an epitheliumsearch carbonate dehydratase activitysearch protein bindingsearch zinc ion bindingsearch lyase activitysearch metal ion bindingsearch cytoplasmsearch plasma membranesearch apical part of cellsearch axonsearch extracellular vesicular exosomesearch cytosolsearch extracellular spacesearch membranesearch microvillussearch basolateral plasma membranesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch