1ugc Summary

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HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY HIS (A65H)

The structure was published by Scolnick, L.R. and Christianson, D.W., in 1996 in a paper entitled "X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 258 residues which is 99% of the natural sequence. Out of 258 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (3-260) (CAH2_HUMAN)search Homo sapienssearch 98% 258 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (3 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) carbonate dehydratase activitysearch zinc ion bindingsearch lyase activitysearch protein bindingsearch metal ion bindingsearch plasma membranesearch cytosolsearch basolateral plasma membranesearch myelin sheathsearch cytoplasmsearch extracellular vesicular exosomesearch axonsearch membranesearch apical part of cellsearch extracellular spacesearch microvillussearch morphogenesis of an epitheliumsearch regulation of anion transportsearch one-carbon metabolic processsearch positive regulation of bone resorptionsearch response to organic substancesearch bicarbonate transportsearch response to steroid hormonesearch positive regulation of synaptic transmission, GABAergicsearch odontogenesis of dentin-containing toothsearch regulation of intracellular pHsearch positive regulation of osteoclast differentiationsearch response to zinc ionsearch angiotensin-activated signaling pathwaysearch response to estrogensearch response to pHsearch kidney developmentsearch positive regulation of cellular pH reductionsearch positive regulation of dipeptide transmembrane transportsearch regulation of chloride transportsearch secretionsearch small molecule metabolic processsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch