1ugb Summary

pdbe.org/1ugb
spacer

HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY GLY (A65G)

The structure was published by Scolnick, L.R. and Christianson, D.W., in 1996 in a paper entitled "X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 258 residues which is 99% of the natural sequence. Out of 258 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (3-260) (CAH2_HUMAN)search Homo sapienssearch 98% 258 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (3 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) protein bindingsearch metal ion bindingsearch zinc ion bindingsearch carbonate dehydratase activitysearch lyase activitysearch cytosolsearch apical part of cellsearch cytoplasmsearch basolateral plasma membranesearch extracellular spacesearch plasma membranesearch extracellular vesicular exosomesearch myelin sheathsearch microvillussearch axonsearch membranesearch response to organic substancesearch response to estrogensearch regulation of anion transportsearch response to steroid hormonesearch bicarbonate transportsearch secretionsearch one-carbon metabolic processsearch kidney developmentsearch regulation of chloride transportsearch angiotensin-activated signaling pathwaysearch response to pHsearch regulation of intracellular pHsearch morphogenesis of an epitheliumsearch positive regulation of osteoclast differentiationsearch positive regulation of bone resorptionsearch response to zinc ionsearch positive regulation of synaptic transmission, GABAergicsearch odontogenesis of dentin-containing toothsearch small molecule metabolic processsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of cellular pH reductionsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch