1ucf Summary

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The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease

The structure was published by Honbou, K., Suzuki, N.N., Horiuchi, M., et al., Taira, T., Ariga, H., and Inagaki, F., in 2003 in a paper entitled "The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of RNA-binding protein regulatory subunit.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RNA-binding protein regulatory subunit Q99497 (1-189) (PARK7_HUMAN)search Homo sapienssearch 99% 189 99%
B RNA-binding protein regulatory subunit Q99497 (1-189) (PARK7_HUMAN)search Homo sapienssearch 99% 189 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q99497 (1 - 189) RNA-binding protein regulatory subunit Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q99497) DJ-1/PfpIsearch Rossmann foldsearch PF01965: DJ-1/PfpI familysearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (Q99497) negative regulation of death-inducing signaling complex assemblysearch positive regulation of L-dopa decarboxylase activitysearch negative regulation of cell deathsearch positive regulation of protein homodimerization activitysearch regulation of mitochondrial membrane potentialsearch positive regulation of superoxide dismutase activitysearch regulation of neuron apoptotic processsearch hydrogen peroxide metabolic processsearch negative regulation of neuron apoptotic processsearch negative regulation of ubiquitin-protein transferase activitysearch cellular response to oxidative stresssearch positive regulation of mitochondrial electron transport, NADH to ubiquinonesearch mitochondrion organizationsearch negative regulation of protein bindingsearch negative regulation of ubiquitin-specific protease activitysearch positive regulation of protein localization to nucleussearch synaptic transmission, dopaminergicsearch negative regulation of extrinsic apoptotic signaling pathwaysearch single fertilizationsearch response to hydrogen peroxidesearch cellular response to hydrogen peroxidesearch cellular response to reactive oxygen speciessearch positive regulation of pyrroline-5-carboxylate reductase activitysearch negative regulation of protein kinase activitysearch negative regulation of protein export from nucleussearch regulation of androgen receptor signaling pathwaysearch negative regulation of hydrogen peroxide-induced neuron deathsearch inflammatory responsesearch dopamine uptake involved in synaptic transmissionsearch negative regulation of protein sumoylationsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaysearch positive regulation of androgen receptor activitysearch positive regulation of L-dopa biosynthetic processsearch positive regulation of transcription from RNA polymerase II promotersearch negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwaysearch positive regulation of interleukin-8 productionsearch methylglyoxal catabolic process to D-lactatesearch glycolate biosynthetic processsearch lactate biosynthetic processsearch response to stresssearch negative regulation of apoptotic processsearch negative regulation of protein K48-linked deubiquitinationsearch regulation of TRAIL receptor biosynthetic processsearch glyoxal catabolic processsearch cellular response to glyoxalsearch negative regulation of protein ubiquitinationsearch protein stabilizationsearch regulation of inflammatory responsesearch negative regulation of neuron deathsearch cell deathsearch positive regulation of tyrosine 3-monooxygenase activitysearch positive regulation of dopamine biosynthetic processsearch negative regulation of TRAIL-activated apoptotic signaling pathwaysearch negative regulation of oxidative stress-induced cell deathsearch membrane hyperpolarizationsearch membrane depolarizationsearch negative regulation of hydrogen peroxide-induced cell deathsearch oxidation-reduction processsearch adult locomotory behaviorsearch positive regulation of oxidative phosphorylation uncoupler activitysearch autophagysearch negative regulation of protein acetylationsearch proteolysissearch negative regulation of protein phosphorylationsearch negative regulation of gene expressionsearch chromatinsearch plasma membranesearch cytoplasmsearch mitochondrionsearch cytosolsearch nucleussearch extracellular vesicular exosomesearch membranesearch membrane raftsearch mitochondrial respiratory chain complex Isearch PML bodysearch ubiquitin-specific protease bindingsearch core promoter bindingsearch protein bindingsearch peptidase activitysearch identical protein bindingsearch peroxiredoxin activitysearch glyoxalase (glycolic acid-forming) activitysearch transcription coactivator activitysearch protein homodimerization activitysearch scaffold protein bindingsearch enzyme bindingsearch repressing transcription factor bindingsearch androgen receptor bindingsearch cupric ion bindingsearch glyoxalase III activitysearch cytokine bindingsearch transcription factor bindingsearch small protein conjugating enzyme bindingsearch cuprous ion bindingsearch oxidoreductase activity, acting on peroxide as acceptorsearch tyrosine 3-monooxygenase activator activitysearch hydrolase activitysearch small protein activating enzyme bindingsearch double-stranded DNA bindingsearch mRNA bindingsearch receptor bindingsearch superoxide dismutase copper chaperone activitysearch peroxidase activitysearch L-dopa decarboxylase activator activitysearch single-stranded DNA bindingsearch RNA bindingsearch

Chain InterPro annotation
A, B ThiJ/PfpIsearch DJ-1search Class I glutamine amidotransferase-likesearch