1ucf Summary

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The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease

The structure was published by Honbou, K., Suzuki, N.N., Horiuchi, M., et al., Taira, T., Ariga, H., and Inagaki, F., in 2003 in a paper entitled "The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of RNA-binding protein regulatory subunit.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RNA-binding protein regulatory subunit Q99497 (1-189) (PARK7_HUMAN)search Homo sapienssearch 99% 189 99%
B RNA-binding protein regulatory subunit Q99497 (1-189) (PARK7_HUMAN)search Homo sapienssearch 99% 189 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q99497 (1 - 189) RNA-binding protein regulatory subunit Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q99497) DJ-1/PfpIsearch Rossmann foldsearch PF01965: DJ-1/PfpI familysearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (Q99497) nucleussearch mitochondrionsearch cytoplasmsearch extracellular vesicular exosomesearch cytosolsearch membranesearch PML bodysearch membrane raftsearch plasma membranesearch double-stranded DNA bindingsearch mRNA bindingsearch receptor bindingsearch protein homodimerization activitysearch small protein activating enzyme bindingsearch RNA bindingsearch protein bindingsearch peroxidase activitysearch peroxiredoxin activitysearch hydrolase activitysearch peptidase activitysearch ubiquitin-specific protease bindingsearch single-stranded DNA bindingsearch superoxide dismutase copper chaperone activitysearch androgen receptor bindingsearch cupric ion bindingsearch scaffold protein bindingsearch enzyme bindingsearch identical protein bindingsearch cuprous ion bindingsearch oxidoreductase activity, acting on peroxide as acceptorsearch cytokine bindingsearch transcription factor bindingsearch small protein conjugating enzyme bindingsearch negative regulation of protein K48-linked deubiquitinationsearch negative regulation of cell deathsearch positive regulation of oxidative phosphorylation uncoupler activitysearch response to stresssearch regulation of inflammatory responsesearch cellular response to oxidative stresssearch protein stabilizationsearch negative regulation of neuron deathsearch regulation of TRAIL receptor biosynthetic processsearch positive regulation of transcription from RNA polymerase II promotersearch negative regulation of protein bindingsearch negative regulation of protein phosphorylationsearch mitochondrion organizationsearch negative regulation of TRAIL-activated apoptotic signaling pathwaysearch cellular response to reactive oxygen speciessearch autophagysearch negative regulation of protein acetylationsearch hydrogen peroxide metabolic processsearch membrane depolarizationsearch adult locomotory behaviorsearch negative regulation of extrinsic apoptotic signaling pathwaysearch response to hydrogen peroxidesearch dopamine uptake involved in synaptic transmissionsearch positive regulation of protein localization to nucleussearch positive regulation of superoxide dismutase activitysearch regulation of mitochondrial membrane potentialsearch regulation of neuron apoptotic processsearch single fertilizationsearch negative regulation of neuron apoptotic processsearch cellular response to hydrogen peroxidesearch negative regulation of ubiquitin-specific protease activitysearch proteolysissearch negative regulation of hydrogen peroxide-mediated programmed cell deathsearch negative regulation of death-inducing signaling complex assemblysearch negative regulation of gene expressionsearch positive regulation of protein homodimerization activitysearch oxidation-reduction processsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaysearch synaptic transmission, dopaminergicsearch positive regulation of androgen receptor activitysearch positive regulation of interleukin-8 productionsearch negative regulation of protein kinase activitysearch negative regulation of protein export from nucleussearch membrane hyperpolarizationsearch cell deathsearch regulation of androgen receptor signaling pathwaysearch inflammatory responsesearch

Chain InterPro annotation
A, B ThiJ/PfpIsearch DJ-1search Class I glutamine amidotransferase-likesearch