1uaq Summary


The crystal structure of yeast cytosine deaminase

The structure was published by Ko, T.-P., Lin, J.-J., Hu, C.-Y., Hsu, Y.-H., Wang, A.H.-J., and Liaw, S.-H., in 2003 in a paper entitled "Crystal structure of yeast cytosine deaminase. Insights into enzyme mechanism and evolution" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of cytosine deaminase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A cytosine deaminase Q12178 (1-158) (FCY1_YEAST)search Saccharomyces cerevisiae S288csearch 100% 158 95%
B cytosine deaminase Q12178 (1-158) (FCY1_YEAST)search Saccharomyces cerevisiae S288csearch 100% 158 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q12178 (1 - 158) cytosine deaminase Saccharomyces cerevisiae

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q12178) Deoxycytidylate deaminase-likesearch Cytidine Deaminase, domain 2search PF00383: Cytidine and deoxycytidylate deaminase zinc-binding regionsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q12178) hydrolase activitysearch catalytic activitysearch zinc ion bindingsearch cytosine deaminase activitysearch metal ion bindingsearch cytidine metabolic processsearch UMP salvagesearch cytosine metabolic processsearch pyrimidine-containing compound salvagesearch

Chain InterPro annotation
A, B CMP/dCMP deaminase, zinc-bindingsearch APOBEC/CMP deaminase, zinc-bindingsearch Cytidine deaminase-likesearch