1uag Summary

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UDP-N-ACETYLMURAMOYL-L-ALANINE:D-GLUTAMATE LIGASE

The structure was published by Bertrand, J.A., Auger, G., Fanchon, E., et al., Blanot, D., van Heijenoort, J., and Dideberg, O., in 1997 in a paper entitled "Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase from Escherichia coli." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of UDP-N-ACETYLMURAMOYL-L-ALANINE/:D-GLUTAMATE LIGASE. This molecule has the UniProt identifier P14900 (MURD_ECOLI)search. The sample contained 437 residues which is 100% of the natural sequence. Out of 437 residues 428 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A UDP-N-ACETYLMURAMOYL-L-ALANINE/:D-GLUTAMATE LIGASE P14900 (2-438) (MURD_ECOLI)search Escherichia coli K-12search 100% 437 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P14900 (2 - 438) UDP-N-ACETYLMURAMOYL-L-ALANINE/:D-GLUTAMATE LIGASE Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P14900) MurCD N-terminal domainsearch, MurCDEF C-terminal domainsearch, MurCDEFsearch NAD(P)-binding Rossmann-like Domainsearch, UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligasesearch, Protein-Tyrosine Phosphatase; Chain Asearch PF02875: Mur ligase family, glutamate ligase domainsearch, PF08245: Mur ligase middle domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P14900) peptidoglycan biosynthetic processsearch cell cyclesearch cell divisionsearch biosynthetic processsearch regulation of cell shapesearch cell wall organizationsearch ligase activitysearch ATP bindingsearch UDP-N-acetylmuramoylalanine-D-glutamate ligase activitysearch nucleotide bindingsearch identical protein bindingsearch cytoplasmsearch

Chain InterPro annotation
A Mur ligase, C-terminalsearch UDP-N-acetylmuramoylalanine-D-glutamate ligasesearch Mur ligase, centralsearch NAD(P)-binding domainsearch