1uae Summary



The structure was published by Skarzynski, T., Mistry, A., Wonacott, A., Hutchinson, S.E., Kelly, V.A., and Duncan, K., in 1996 in a paper entitled "Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE. This molecule has the UniProt identifier P0A749 (MURA_ECOLI)search. The sample contained 419 residues which is 100% of the natural sequence. Out of 419 residues 418 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE P0A749 (1-419) (MURA_ECOLI)search Escherichia coli K-12search 100% 419 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P0A749) Enolpyruvate transferase, EPTsearch UDP-n-acetylglucosamine1-carboxyvinyl-transferase; Chainsearch PF00275: EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P0A749) catalytic activitysearch transferase activity, transferring alkyl or aryl (other than methyl) groupssearch UDP-N-acetylglucosamine 1-carboxyvinyltransferase activitysearch transferase activitysearch UDP-N-acetylgalactosamine biosynthetic processsearch peptidoglycan biosynthetic processsearch cell cyclesearch cell wall organizationsearch cell divisionsearch regulation of cell shapesearch cytoplasmsearch

Chain InterPro annotation
A Enolpyruvate transferase domainsearch UDP-N-acetylglucosamine 1-carboxyvinyltransferasesearch RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/betasearch