1ua2 Summary

pdbe.org/1ua2
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Crystal Structure of Human CDK7

The structure was published by Lolli, G., Lowe, E.D., Brown, N.R., and Johnson, L.N., in 2004 in a paper entitled "The Crystal Structure of Human CDK7 and Its Protein Recognition Properties" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.02 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Cell division protein kinase 7.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 7 P50613 (1-346) (CDK7_HUMAN)search Homo sapienssearch 100% 346 82%
B Cell division protein kinase 7 P50613 (1-346) (CDK7_HUMAN)search Homo sapienssearch 100% 346 82%
C Cell division protein kinase 7 P50613 (1-346) (CDK7_HUMAN)search Homo sapienssearch 100% 346 82%
D Cell division protein kinase 7 P50613 (1-346) (CDK7_HUMAN)search Homo sapienssearch 100% 346 82%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P50613 (1 - 346) Cell division protein kinase 7 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P50613) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D (P50613) protein kinase activitysearch ATP bindingsearch RNA polymerase II carboxy-terminal domain kinase activitysearch transferase activitysearch kinase activitysearch protein serine/threonine kinase activitysearch DNA-dependent ATPase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch transcription coactivator activitysearch androgen receptor bindingsearch nucleotide bindingsearch protein C-terminus bindingsearch protein bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch transcription elongation from RNA polymerase II promotersearch androgen receptor signaling pathwaysearch positive regulation of transcription, DNA-templatedsearch transcription initiation from RNA polymerase I promotersearch ATP catabolic processsearch viral processsearch positive regulation of viral transcriptionsearch regulation of transcription, DNA-templatedsearch transcription elongation from RNA polymerase I promotersearch gene expressionsearch transcription from RNA polymerase II promotersearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch G1/S transition of mitotic cell cyclesearch transcription initiation from RNA polymerase II promotersearch cell proliferationsearch termination of RNA polymerase I transcriptionsearch DNA repairsearch nucleotide-excision repairsearch G2/M transition of mitotic cell cyclesearch transcription from RNA polymerase I promotersearch cell cyclesearch cell divisionsearch cellular response to DNA damage stimulussearch mitotic cell cyclesearch phosphorylationsearch positive regulation of transcription from RNA polymerase II promotersearch transcription-coupled nucleotide-excision repairsearch 7-methylguanosine mRNA cappingsearch nucleotide-excision repair, DNA damage removalsearch cell cycle arrestsearch transcription, DNA-templatedsearch nucleoplasmsearch nucleussearch cytoplasmsearch holo TFIIH complexsearch mitochondrionsearch perinuclear region of cytoplasmsearch

Chain InterPro annotation
A, B, C, D Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch