› 1u9o

X-ray diffraction
3.3Å resolution

Crystal structure of the transcriptional regulator EthR in a ligand bound conformation

Released:
DOI: 10.2210/pdb1u9o/pdb
PDB entry 1u9o coloured by chain, front view.
PDB entry 1u9o coloured by chain, side view.
PDB entry 1u9o coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Structure of EthR in a ligand bound conformation reveals therapeutic perspectives against tuberculosis.
Frénois F, Engohang-Ndong J, Locht C, Baulard AR, Villeret V
Mol Cell 16 301-7 (2004)
PMID: 15494316

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161781 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH-type transcriptional regulator EthR Chains: A, B
Molecule details ›
Chains: A, B
Length: 236 amino acids
Theoretical weight: 25.92 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Mycolicibacterium smegmatis
UniProt:
  • Canonical: P9WMC1 (Residues: 1-216; Coverage: 100%)
Gene names: Rv3855, etaR, ethR
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CNS 2 x CNS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR571
Spacegroup: R3
Unit cell:
a: 140.5Å b: 140.5Å c: 76.69Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.232 0.217 0.277
Expression system: Mycolicibacterium smegmatis

Quick links

Citations

20 review citations

The TetR family of regulators.
Cuthbertson et al. (2013)
19 more

5 mentions without citation

Automated refinement of macromolecular structures at low resolution using prior information.
Kovalevskiy et al. (2016)
4 more