1u7f Summary

pdbe.org/1u7f
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Crystal Structure of the phosphorylated Smad3/Smad4 heterotrimeric complex

The structure was published by Chacko, B.M., Qin, B.Y., Tiwari, A., et al., Hayward, L.J., De Caestecker, M., and Lin, K., in 2004 in a paper entitled "Structural basis of heteromeric smad protein assembly in tgf-Beta signaling" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Mothers against decapentaplegic homolog 3 and Mothers against decapentaplegic homolog 4.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mothers against decapentaplegic homolog 3 P84022 (228-425) (SMAD3_HUMAN)search Homo sapienssearch < 90% 198 100%
C Mothers against decapentaplegic homolog 3 P84022 (228-425) (SMAD3_HUMAN)search Homo sapienssearch < 90% 198 100%
B Mothers against decapentaplegic homolog 4 Q13485 (314-552) (SMAD4_HUMAN)search Homo sapienssearch < 90% 239 80%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P84022 (228 - 425) Mothers against decapentaplegic homolog 3 Homo sapiens
Q13485 (314 - 552) Mothers against decapentaplegic homolog 4 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C SMAD domainsearch Tumour Suppressor Smad4search MH2 domainsearch
B SMAD domainsearch Tumour Suppressor Smad4search MH2 domainsearch

Chain ID Cellular component (GO) Biological process (GO)
A, C (P84022) intracellularsearch regulation of transcription, DNA-templatedsearch
B (Q13485) intracellularsearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A, C SMAD domain, Dwarfin-typesearch SMAD/FHA domainsearch Dwarfinsearch SMAD domain-likesearch
B SMAD domain, Dwarfin-typesearch SMAD/FHA domainsearch Dwarfinsearch SMAD domain-likesearch