1u67 Summary


Crystal Structure of Arachidonic Acid Bound to a Mutant of Prostagladin H Synthase-1 that Forms Predominantly 11-HPETE.

The structure was published by Harman, C.A., Rieke, C.J., Garavito, R.M., and Smith, W.L., in 2004 in a paper entitled "Crystal structure of arachidonic Acid bound to a mutant of prostaglandin endoperoxide h synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic Acid." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.1 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Prostaglandin G/H synthase 1 precursor. This molecule has the UniProt identifier P05979 (PGH1_SHEEP)search. The sample contained 600 residues which is < 90% of the natural sequence. Out of 600 residues 532 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin G/H synthase 1 precursor P05979 (1-600) (PGH1_SHEEP)search Ovis ariessearch 96% 600 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05979 (1 - 600) Prostaglandin G/H synthase 1 precursor Ovis aries

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P05979) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P05979) peroxidase activitysearch prostaglandin-endoperoxide synthase activitysearch heme bindingsearch cyclooxygenase pathwaysearch inflammatory responsesearch response to oxidative stresssearch oxidation-reduction processsearch prostaglandin biosynthetic processsearch regulation of blood pressuresearch

Chain InterPro annotation
A Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 1search