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Crystal Structure of Arachidonic Acid Bound to a Mutant of Prostagladin H Synthase-1 that Forms Predominantly 11-HPETE.

Source organism: Ovis aries
Biochemical function: heme binding
Biological process: response to oxidative stress
Cellular component: not assigned

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EC 1.14.99.1: Prostaglandin-endoperoxide synthase

Reaction catalysed:
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O
Systematic name:
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase
Alternative Name(s):
  • (PG)H synthase
  • Fatty acid cyclooxygenase
  • PG synthetase
  • Prostaglandin G/H synthase
  • Prostaglandin endoperoxide synthetase
  • Prostaglandin synthase
  • Prostaglandin synthetase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF03098
Domain description: Animal haem peroxidase
Occurring in:
  1. Prostaglandin G/H synthase 1
The deposited structure of PDB entry 1u67 contains 1 copy of Pfam domain PF03098 (Animal haem peroxidase) in Prostaglandin G/H synthase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR019791
Domain description: Haem peroxidase, animal-type
Occurring in:
  1. Prostaglandin G/H synthase 1
IPR000742
Domain description: EGF-like domain
Occurring in:
  1. Prostaglandin G/H synthase 1
IPR037120
Domain description: Haem peroxidase domain superfamily, animal type
Occurring in:
  1. Prostaglandin G/H synthase 1
IPR010255
Domain description: Haem peroxidase superfamily
Occurring in:
  1. Prostaglandin G/H synthase 1

Structure domains

CATH CATH domains
1.10.640.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Myeloperoxidase, subunit C
Homology: Haem peroxidase domain superfamily, animal type
Occurring in:
  1. Prostaglandin G/H synthase 1
The deposited structure of PDB entry 1u67 contains 1 copy of CATH domain 1.10.640.10 (Myeloperoxidase, subunit C) in Prostaglandin G/H synthase 1. Showing 1 copy in chain A.
2.10.25.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Laminin
Homology: Laminin
Occurring in:
  1. Prostaglandin G/H synthase 1
The deposited structure of PDB entry 1u67 contains 1 copy of CATH domain 2.10.25.10 (Laminin) in Prostaglandin G/H synthase 1. Showing 1 copy in chain A.
SCOP SCOP annotations
48132
Class: All alpha proteins
Fold: Heme-dependent peroxidases
Superfamily: Heme-dependent peroxidases
Occurring in:
  1. Prostaglandin G/H synthase 1
The deposited structure of PDB entry 1u67 contains 1 copy of SCOP domain 48132 (Myeloperoxidase-like) in Prostaglandin G/H synthase 1. Showing 1 copy in chain A.
57197
Class: Small proteins
Fold: Knottins (small inhibitors, toxins, lectins)
Superfamily: EGF/Laminin
Occurring in:
  1. Prostaglandin G/H synthase 1
The deposited structure of PDB entry 1u67 contains 1 copy of SCOP domain 57197 (EGF-type module) in Prostaglandin G/H synthase 1. Showing 1 copy in chain A.

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