1u5s Summary

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NMR structure of the complex between Nck-2 SH3 domain and PINCH-1 LIM4 domain

The structure was published by Vaynberg, J., Fukuda, T., Chen, K., et al., Ng, L., Wu, C., and Qin, J., in 2005 in a paper entitled "Structure of an ultraweak protein-protein complex and its crucial role in regulation of cell morphology and motility." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2004.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Cytoplasmic protein NCK2 and PINCH protein.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cytoplasmic protein NCK2 O43639 (192-262) (NCK2_HUMAN)search Homo sapienssearch < 90% 71 100%
B PINCH protein P48059 (188-251) (LIMS1_HUMAN)search Homo sapienssearch < 90% 66 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
O43639 (192 - 262) Cytoplasmic protein NCK2 Homo sapiens
P48059 (188 - 251) PINCH protein Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH3-domainsearch SH3 Domainssearch SH3 domainsearch
B LIM domainsearch Cysteine Rich Proteinsearch LIM domainsearch

Chain ID Molecular function (GO)
B (P48059) zinc ion bindingsearch

Chain InterPro annotation
A SH3 domainsearch Cytoplasmic protein NCK2search
B Zinc finger, LIM-typesearch LIM and senescent cell antigen-like-containing domain protein 1search