1u5r Summary

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Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K

The structure was published by Zhou, T., Raman, M., Gao, Y., et al., Machius, M., Cobb, M.H., and Goldsmith, E.J., in 2004 in a paper entitled "Crystal Structure of the TAO2 Kinase Domain; Activation and Specificity of a Ste20p MAP3K." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of serine/threonine protein kinase TAO2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A serine/threonine protein kinase TAO2 Q9JLS3 (1-320) (TAOK2_RAT)search Rattus norvegicussearch < 90% 348 88%
B serine/threonine protein kinase TAO2 Q9JLS3 (1-320) (TAOK2_RAT)search Rattus norvegicussearch < 90% 348 88%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9JLS3 (1 - 320) serine/threonine protein kinase TAO2 Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q9JLS3) protein kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch