1u59 Summary


Crystal Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine

The structure was published by Jin, L., Pluskey, S., Petrella, E.C., et al., Babine, R.E., Weaver, D.T., and Seidl, K.J., in 2004 in a paper entitled "The Three-dimensional Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine: IMPLICATIONS FOR THE DESIGN OF SELECTIVE INHIBITORS" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Tyrosine-protein kinase ZAP-70. This molecule has the UniProt identifier P43403 (ZAP70_HUMAN)search. The sample contained 287 residues which is < 90% of the natural sequence. Out of 287 residues 282 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein kinase ZAP-70 P43403 (327-606) (ZAP70_HUMAN)search Homo sapienssearch 98% 287 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P43403 (327 - 606) Tyrosine-protein kinase ZAP-70 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P43403) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF07714: Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (P43403) protein phosphorylationsearch protein kinase activitysearch ATP bindingsearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch