1u54 Summary

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Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the CDC42-associated Tyrosine Kinase ACK1 bound to AMP-PCP

The structure was published by Lougheed, J.C., Chen, R.H., Mak, P., and Stout, T.J., in 2004 in a paper entitled "Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Activated CDC42 kinase 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Activated CDC42 kinase 1 Q07912 (109-395) (ACK1_HUMAN)search Homo sapienssearch < 90% 291 90%
B Activated CDC42 kinase 1 Q07912 (109-395) (ACK1_HUMAN)search Homo sapienssearch < 90% 291 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q07912 (109 - 395) Activated CDC42 kinase 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch, Variant SH3 domainsearch
B Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch, Variant SH3 domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q07912) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch protein phosphorylationsearch
B (Q07912) protein tyrosine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch
B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch