1u3s Summary

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Crystal Structure of Estrogen Receptor beta complexed with WAY-797

The structure was published by Malamas, M.S., Manas, E.S., McDevitt, R.E., et al., Henderson, R.A., Keith Jr., J.C., and Harris, H.A., in 2004 in a paper entitled "Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Estrogen receptor beta and steroid receptor coactivator-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen receptor beta Q92731 (261-500) (ESR2_HUMAN)search Homo sapienssearch < 90% 240 94%
B Estrogen receptor beta Q92731 (261-500) (ESR2_HUMAN)search Homo sapienssearch < 90% 240 94%
C steroid receptor coactivator-1 Q15788 (630-640) (NCOA1_HUMAN)search Homo sapienssearch < 90% 13 69%
D steroid receptor coactivator-1 Not available
Synthetic < 90% 13 69%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q92731 (261 - 500) Estrogen receptor beta Homo sapiens
Q15788 (630 - 640) steroid receptor coactivator-1

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
C, D Steroid receptor coactivatorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q92731) steroid hormone receptor activitysearch thyroid hormone receptor activitysearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch steroid hormone mediated signaling pathwaysearch regulation of transcription, DNA-templatedsearch nucleussearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
C, D