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Crystal structure of Mycobacterium tuberculosis Low Molecular Protein Tyrosine Phosphatase (MPtpA) at 1.9A resolution

X-ray diffraction
1.9Å resolution
PDB entry 1u2p coloured by chain, front view.
PDB entry 1u2p coloured by chain, side view.
PDB entry 1u2p coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Low molecular weight protein-tyrosine phosphatase A
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Multimeric state: monomeric
Accessible surface area: 7801.21 Å2
Buried surface area: 148.86 Å2
Dissociation area: 74.43 Å2
Dissociation energy (ΔGdiss): 12.17 kcal/mol
Dissociation entropy (TΔSdiss): -0.83 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-161611

Macromolecules

Low molecular weight protein-tyrosine phosphatase A
Chain: A
Length: 163 amino acids
Theoretical weight: 17.92 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WIA1 (Residues: 1-163; Coverage: 100%)
Gene names: MTCY427.15, Rv2234, mptpA, ptpA
Pfam: Low molecular weight phosphotyrosine protein phosphatase
InterPro:
CATH: Rossmann fold
Low molecular weight protein-tyrosine phosphatase A in PDB entry 1u2p, assembly 1, front view.
Low molecular weight protein-tyrosine phosphatase A in PDB entry 1u2p, assembly 1, side view.
Low molecular weight protein-tyrosine phosphatase A in PDB entry 1u2p, assembly 1, top view.
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