1u0s Summary

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Chemotaxis kinase CheA P2 domain in complex with response regulator CheY from the thermophile thermotoga maritima

The structure was published by Park, S.Y., Beel, B.D., Simon, M.I., Bilwes, A.M., and Crane, B.R., in 2004 in a paper entitled "In different organisms, the mode of interaction between two signaling proteins is not necessarily conserved" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Chemotaxis protein cheY and Chemotaxis protein cheA.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
Y Chemotaxis protein cheY Q56312 (2-119) (CHEY_THEMA)search Thermotoga maritima MSB8search 98% 118 100%
A Chemotaxis protein cheA Q56310 (175-260) (CHEA_THEMA)search Thermotoga maritima MSB8search < 90% 86 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q56312 (2 - 119) Chemotaxis protein cheY Thermotoga maritima
Q56310 (175 - 260) Chemotaxis protein cheA Thermotoga maritima

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
Y (Q56312) CheY-relatedsearch Rossmann foldsearch PF00072: Response regulator receiver domainsearch
A CheY-binding domain of CheAsearch CheY-binding domain of CheA. Chain Asearch P2 response regulator binding domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
Y (Q56312) phosphorelay signal transduction systemsearch chemotaxissearch archaeal or bacterial-type flagellum-dependent cell motilitysearch intracellular signal transductionsearch phosphorelay response regulator activitysearch metal ion bindingsearch protein bindingsearch cytoplasmsearch
A (Q56310) cellular component movementsearch phosphorelay signal transduction systemsearch phosphorelay sensor kinase activitysearch protein histidine kinase activitysearch

Chain InterPro annotation
Y Signal transduction response regulator, receiver domainsearch CheY-like superfamilysearch
A Signal transduction histidine kinase, P2 response regulator-bindingsearch CheY bindingsearch