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EBI PDBe PDBeView

PDBe Entry: 1u0m view

Crystal Structure of 1,3,6,8-Tetrahydroxynaphthalene Synthase (THNS) from Streptomyces coelicolor A3(2): a Bacterial Type III Polyketide Synthase (PKS) Provides Insights into Enzymatic Control of Reactive Polyketide Intermediates
Summary
Header BIOSYNTHETIC PROTEINsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.22 Å, R-factor: 25.5%, Free R-factor: 29.2%, Spacegroup: P 1 21 1
Released 14/09/2004, deposition: 13/07/2004, last revision: 24/02/2009
Authors Austin, M.B.search; Izumikawa, M.search; Bowman, M.E.search; Udwary, D.W.search; Ferrer, J.L.search; Moore, B.S.search; Noel, J.P.search
Primary citation Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates
J.BIOL.CHEM.search vol:279, pag:45162-45174 (2004) [PubMed ID 15265863 ]search
Keywords type III polyketide synthasesearch, PKSsearch, bacterialsearch, thiolase foldsearch, alpha-beta-alpha-beta-alpha foldsearch, catalytic triadsearch, CHS-likesearch, THNSsearch, tetrahydroxynaphthalene synthasesearch, chalcone/stilbene synthase superfamilysearch, malonyl-CoAsearch, BIOSYNTHETIC PROTEINsearch
Organism Streptomyces coelicolor A3(2) 100226search(A B)
UniProt Putative polyketide synthase Q9FCA7search (A B)
Solvent A, B
Polymers
Id Name Type UniProt Residues Observed
A, B putative polyketide synthase Protein Q9FCA7 (Q9FCA7_STRCO)search
 382 91%
Heterogens
Id Name Ligands
A, B POLYETHYLENE GLYCOL (N=34) 15P search
A, B GLYCEROL GOL search
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