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PDBe Entry: 1u0h 
STRUCTURAL BASIS FOR THE INHIBITION OF MAMMALIAN ADENYLYL CYCLASE BY MANT-GTP
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LYASE
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X-RAY DIFFRACTION
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Resolution: 2.9 Å, R-factor: 24.55%, Free R-factor: 27.98%, Spacegroup: P 21 21 2
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14/12/2004, deposition: 13/07/2004, last revision: 24/02/2009
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Mou, T.C.; Gille, A.; Seifert, R.J.; Sprang, S.R.
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Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate.
J.BIOL.CHEM. vol:280, pag:7253-7261 (2005) [PubMed ID 15591060 ]
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adenylyl cyclase, Gsa, MANT-GTP, LYASE
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4.6.1.1 ExPASy BRENDA (A B)
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Canis lupus familiaris(dog) 9615(A),Rattus norvegicus(Norway rat) 10116(B),Bos taurus(cattle) 9913(C)
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Adenylate cyclase type 5 (EC 4.6.1.1) (Adenylate cyclase type V) (ATP pyrophosphate-lyase 5) (Adenylyl cyclase 5) (Ca(2+)-inhibitable adenylyl cyclase) P30803 (A)
Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) P26769 (B)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein) P04896 (C)
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A, B, C
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1tl7
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| A |
Adenylate cyclase, type V |
Protein |
P30803 (ADCY5_CANFA)
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225 |
84% |
| B |
Adenylate cyclase, type II |
Protein |
P26769 (ADCY2_RAT)
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212 |
89% |
| C |
Guanine nucleotide-binding protein G(s), alpha subunit |
Protein |
P04896 (GNAS2_BOVIN)
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394 |
83% |
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| C, A |
MAGNESIUM ION |
MG
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| C |
CHLORIDE ION |
CL
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| C |
5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE |
GSP
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| A |
FORSKOLIN |
FOK
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| A |
3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE |
ONM
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