1tzy Summary

pdbe.org/1tzy
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Crystal Structure of the Core-Histone Octamer to 1.90 Angstrom Resolution

The structure was published by Wood, C.M., Nicholson, J.M., Lambert, S.J., Chantalat, L., Reynolds, C.D., and Baldwin, J.P., in 2005 in a paper entitled "High-resolution structure of the native histone octamer." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This entry contains 44 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterooctamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Histone H2A-IV P02263 (1-129) (H2A4_CHICK)search Gallus gallussearch 99% 129 82%
E Histone H2A-IV P02263 (1-129) (H2A4_CHICK)search Gallus gallussearch 99% 129 82%
B Histone H2B P0C1H5 (1-126) (H2B7_CHICK)search Gallus gallussearch 99% 126 73%
F Histone H2B P0C1H5 (1-126) (H2B7_CHICK)search Gallus gallussearch 99% 126 73%
C HISTONE H3 P84229 (1-136) (H32_CHICK)search Gallus gallussearch 99% 136 72%
G HISTONE H3 P84229 (1-136) (H32_CHICK)search Gallus gallussearch 99% 136 72%
D HISTONE H4-VI P62801 (1-103) (H4_CHICK)search Gallus gallussearch 99% 103 81%
H HISTONE H4-VI P62801 (1-103) (H4_CHICK)search Gallus gallussearch 99% 103 81%


This entry contains 4 unique UniProt proteins:

UniProt accession Name Organism PDB
P02263 (1 - 129) Histone H2A-IV Gallus gallus
P0C1H5 (1 - 126) Histone H2B Gallus gallus
P84229 (1 - 136) HISTONE H3 Gallus gallus
P62801 (1 - 103) HISTONE H4-VI Gallus gallus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, E (P02263) Nucleosome core histonessearch Histone, subunit Asearch PF00125: Core histone H2A/H2B/H3/H4search
B, F (P0C1H5) Nucleosome core histonessearch Histone, subunit Asearch PF00125: Core histone H2A/H2B/H3/H4search
C, G (P84229) Nucleosome core histonessearch Histone, subunit Asearch PF00125: Core histone H2A/H2B/H3/H4search
D, H (P62801) Nucleosome core histonessearch Histone, subunit Asearch PF00125: Core histone H2A/H2B/H3/H4search

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, E (P02263) nucleosomesearch nucleussearch chromosomesearch DNA bindingsearch protein heterodimerization activitysearch
B, F (P0C1H5) nucleosomesearch chromosomesearch lipid particlesearch nucleussearch NuA4 histone acetyltransferase complexsearch DNA bindingsearch protein heterodimerization activitysearch
C, G (P84229) nucleosomesearch extracellular vesicular exosomesearch nucleussearch chromosomesearch DNA bindingsearch protein heterodimerization activitysearch
D, H (P62801) nucleosomesearch nucleussearch chromosomesearch protein complexsearch nuclear chromosomesearch extracellular vesicular exosomesearch nucleoplasmsearch DNA bindingsearch protein heterodimerization activitysearch poly(A) RNA bindingsearch nucleosome assemblysearch negative regulation of megakaryocyte differentiationsearch DNA replication-dependent nucleosome assemblysearch DNA replication-independent nucleosome assemblysearch

Chain InterPro annotation
A, E Histone H2Asearch Histone coresearch Histone-foldsearch
B, F Histone H2Bsearch Histone coresearch Histone-foldsearch
C, G Histone H3/CENP-Asearch Histone coresearch Histone-foldsearch
D, H Histone H4search Histone coresearch Histone-foldsearch Histone H4, conserved sitesearch