1tze Summary

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SIGNAL TRANSDUCTION ADAPTOR GROWTH FACTOR, GRB2 SH2 DOMAIN COMPLEXED WITH PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 (KFPPYVNC-NH2)

The structure was published by Rahuel, J., Gay, B., Erdmann, D., et al., Fretz, H., Schoepfer, J., and Grutter, M.G., in 1996 in a paper entitled "Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 and PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
E GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 P62993 (55-152) (GRB2_HUMAN)search Homo sapienssearch 100% 98 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62993 (55 - 152) GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
E (P62993) SH2 domainsearch SHC Adaptor Proteinsearch PF00017: SH2 domainsearch
Chain InterPro annotation
E SH2 domainsearch