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THE STRUCTURE OF A COMPLEX OF HEXAMERIC INSULIN AND 4'-HYDROXYACETANILIDE

X-ray diffraction
1.9Å resolution
PDB entry 1tym coloured by chain, front view.
PDB entry 1tym coloured by chain, side view.
PDB entry 1tym coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero dimer (preferred)
hetero dodecamer
hetero tetramer
hetero hexamer
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Insulin complex
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Multimeric state: hetero dimer
Accessible surface area: 3473.2 Å2
Buried surface area: 1611.32 Å2
Dissociation area: 770.56 Å2
Dissociation energy (ΔGdiss): 9.25 kcal/mol
Dissociation entropy (TΔSdiss): 8.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134182
Complex Portal ID: CPX-943
Assembly 2 (preferred)
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Assembly Name: Insulin complex
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Multimeric state: hetero dimer
Accessible surface area: 3584.72 Å2
Buried surface area: 1766.84 Å2
Dissociation area: 661.7 Å2
Dissociation energy (ΔGdiss): 5.16 kcal/mol
Dissociation entropy (TΔSdiss): 7.98 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134182
Complex Portal ID: CPX-943
Assembly 3
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Assembly Name: Insulin A chain
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Multimeric state: hetero dodecamer
Accessible surface area: 12445.06 Å2
Buried surface area: 18226.47 Å2
Dissociation area: 130.73 Å2
Dissociation energy (ΔGdiss): 31.17 kcal/mol
Dissociation entropy (TΔSdiss): 1.13 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134235
Assembly 4
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Assembly Name: Insulin A chain
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Multimeric state: hetero tetramer
Accessible surface area: 6064.34 Å2
Buried surface area: 4373.74 Å2
Dissociation area: 817.52 Å2
Dissociation energy (ΔGdiss): 9.85 kcal/mol
Dissociation entropy (TΔSdiss): 8.5 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134210
Assembly 5
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Assembly Name: Insulin A chain
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Multimeric state: hetero tetramer
Accessible surface area: 5650.44 Å2
Buried surface area: 4785.64 Å2
Dissociation area: 686.65 Å2
Dissociation energy (ΔGdiss): 4.44 kcal/mol
Dissociation entropy (TΔSdiss): 8.49 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134210
Assembly 6
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Assembly Name: Insulin A chain
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Multimeric state: hetero hexamer
Accessible surface area: 9363.98 Å2
Buried surface area: 6245.78 Å2
Dissociation area: 876.34 Å2
Dissociation energy (ΔGdiss): 17.56 kcal/mol
Dissociation entropy (TΔSdiss): 20.38 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134224
Assembly 7
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Assembly Name: Insulin A chain
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Multimeric state: hetero hexamer
Accessible surface area: 9964.33 Å2
Buried surface area: 5097.44 Å2
Dissociation area: 237.29 Å2
Dissociation energy (ΔGdiss): 22.18 kcal/mol
Dissociation entropy (TΔSdiss): 18.87 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134224

Macromolecules

Insulin A chain
Chains: A, C
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
InterPro:
SCOP: Insulin-like
Insulin A chain in PDB entry 1tym, assembly 2, front view.
Insulin A chain in PDB entry 1tym, assembly 2, side view.
Insulin A chain in PDB entry 1tym, assembly 2, top view.
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Insulin B chain
Chains: B, D
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:
SCOP: Insulin-like
Insulin B chain in PDB entry 1tym, assembly 2, front view.
Insulin B chain in PDB entry 1tym, assembly 2, side view.
Insulin B chain in PDB entry 1tym, assembly 2, top view.
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