1txg Summary

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Structure of glycerol-3-phosphate dehydrogenase from Archaeoglobus fulgidus

The structure was published by Sakasegawa, S., Hagemeier, C.H., Thauer, R.K., Essen, L.O., and Shima, S., in 2004 in a paper entitled "Structural and functional analysis of the gpsA gene product of Archaeoglobus fulgidus: A glycerol-3-phosphate dehydrogenase with an unusual NADP+ preference" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of glycerol-3-phosphate dehydrogenase [NAD(P)+].

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A glycerol-3-phosphate dehydrogenase [NAD(P)+] O29390 (1-335) (GPDA_ARCFU)search Archaeoglobus fulgidus DSM 4304search 100% 335 100%
B glycerol-3-phosphate dehydrogenase [NAD(P)+] O29390 (1-335) (GPDA_ARCFU)search Archaeoglobus fulgidus DSM 4304search 100% 335 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O29390 (1 - 335) glycerol-3-phosphate dehydrogenase [NAD(P)+] Archaeoglobus fulgidus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (O29390) Glycerol-3-phosphate dehydrogenasesearch, 6-phosphogluconate dehydrogenase-like, N-terminal domainsearch NAD(P)-binding Rossmann-like Domainsearch, N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2search PF01210: NAD-dependent glycerol-3-phosphate dehydrogenase N-terminussearch, PF07479: NAD-dependent glycerol-3-phosphate dehydrogenase C-terminussearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (O29390) glycerol-3-phosphate dehydrogenase [NAD+] activitysearch oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorsearch NAD bindingsearch coenzyme bindingsearch oxidoreductase activitysearch glycerol-3-phosphate dehydrogenase [NAD(P)+] activitysearch glycerol-3-phosphate dehydrogenase [NADP+] activitysearch oxidation-reduction processsearch glycerol-3-phosphate metabolic processsearch glycerol-3-phosphate catabolic processsearch glycerophospholipid metabolic processsearch carbohydrate metabolic processsearch phospholipid biosynthetic processsearch glycerol-3-phosphate biosynthetic processsearch lipid metabolic processsearch cytoplasmsearch glycerol-3-phosphate dehydrogenase complexsearch

Chain InterPro annotation
A, B Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminalsearch Glycerol-3-phosphate dehydrogenase, NAD-dependentsearch 6-phosphogluconate dehydrogenase, C-terminal-likesearch Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminalsearch Dehydrogenase, multihelicalsearch NAD(P)-binding domainsearch