1tup Summary

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TUMOR SUPPRESSOR P53 COMPLEXED WITH DNA

The structure was published by Cho, Y., Gorina, S., Jeffrey, P.D., and Pavletich, N.P., in 1994 in a paper entitled "Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely DNA (5'-D(*TP*TP*TP*CP*CP*TP*AP*GP*AP*CP*TP*TP*GP*CP*CP*CP*A P*AP*TP*TP*A)-3'), DNA (5'-D(*AP*TP*AP*AP*TP*TP*GP*GP*GP*CP*AP*AP*GP*TP*CP*TP*A P*GP*GP*AP*A)-3'), and PROTEIN (P53 TUMOR SUPPRESSOR ).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heteropentamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (P53 TUMOR SUPPRESSOR ) P04637 (94-312) (P53_HUMAN)search Homo sapienssearch < 90% 219 89%
B PROTEIN (P53 TUMOR SUPPRESSOR ) P04637 (94-312) (P53_HUMAN)search Homo sapienssearch < 90% 219 89%
C PROTEIN (P53 TUMOR SUPPRESSOR ) P04637 (94-312) (P53_HUMAN)search Homo sapienssearch < 90% 219 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04637 (94 - 312) PROTEIN (P53 TUMOR SUPPRESSOR ) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C p53 DNA-binding domain-likesearch Immunoglobulin-likesearch P53 DNA-binding domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C (P04637) DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch transcription regulatory region DNA bindingsearch apoptotic processsearch regulation of transcription, DNA-templatedsearch nucleussearch

Chain InterPro annotation
A, B, C p53 tumour suppressor familysearch p53-like transcription factor, DNA-bindingsearch p53, DNA-binding domainsearch p53/RUNT-type transcription factor, DNA-binding domainsearch