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PDBe Entry: 1tu6 
Cathepsin K complexed with a ketoamide inhibitor
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HYDROLASE
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X-RAY DIFFRACTION
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Resolution: 1.75 Å, R-factor: 19.0%, Free R-factor: 21.4%, Spacegroup: P 21 21 21
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21/09/2004, deposition: 24/06/2004, last revision: 24/02/2009
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Barrett, D.G.; Catalano, J.G.; Deaton, D.N.; Hassell, A.M.; Long, S.T.; Miller, A.B.; Miller, L.R.; Shewchuk, L.M.; Wells-Knecht, K.J.; Wright, L.L.
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Potent and selective P2-P3 ketoamide inhibitors of cathepsin K with improved pharmacokinetic properties via favorable P1', P1, and/or P3 substitutions
BIOORG.MED.CHEM.LETT. vol:14, pag:4897-4902 (2004) [PubMed ID 15341947 ]
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catk, cysteine protease, HYDROLASE
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3.4.22.38 ExPASy BRENDA (A B)
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Homo sapiens(human) 9606(A B)
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Cathepsin K precursor (EC 3.4.22.38) (Cathepsin O) (Cathepsin X) (Cathepsin O2) P43235 (A B)
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A, B
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| A, B |
Cathepsin K |
Protein |
P43235 (CATK_HUMAN)
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215 |
100% |
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| A, B |
SULFATE ION |
SO4
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| A, B |
[1-(4-FLUOROBENZYL)CYCLOBUTYL]METHYL (1S)-1-[OXO(1H-PYRAZOL-5-YLAMINO)ACETYL]PENTYLCARBAMATE |
FSP
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