1ttm Summary


Human carbonic anhydrase II complexed with 667-coumate

The structure was published by Lloyd, M.D., Pederick, R.L., Natesh, R., et al., Reed, M.J., Acharya, K.R., and Potter, B.V.L., in 2005 in a paper entitled "Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 99% of the natural sequence. Out of 259 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase II P00918 (2-259) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 259) Carbonic anhydrase II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) one-carbon metabolic processsearch response to estrogensearch bicarbonate transportsearch response to organic substancesearch kidney developmentsearch positive regulation of cellular pH reductionsearch response to steroid hormonesearch angiotensin-activated signaling pathwaysearch regulation of chloride transportsearch positive regulation of osteoclast differentiationsearch positive regulation of dipeptide transmembrane transportsearch secretionsearch positive regulation of bone resorptionsearch positive regulation of synaptic transmission, GABAergicsearch response to zinc ionsearch odontogenesis of dentin-containing toothsearch regulation of intracellular pHsearch regulation of anion transportsearch small molecule metabolic processsearch response to pHsearch morphogenesis of an epitheliumsearch carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch lyase activitysearch protein bindingsearch axonsearch apical part of cellsearch basolateral plasma membranesearch cytoplasmsearch cytosolsearch plasma membranesearch extracellular vesicular exosomesearch myelin sheathsearch microvillussearch membranesearch extracellular spacesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch