› 1ttl

Solution NMR

Omega-conotoxin GVIA, a N-type calcium channel blocker

Released:
DOI: 10.2210/pdb1ttl/pdb
PDB entry 1ttl coloured by chain, ensemble of 20 models, front view.
PDB entry 1ttl coloured by chain, ensemble of 20 models, side view.
PDB entry 1ttl coloured by chain, ensemble of 20 models, top view.
Source organism: Conus geographus
Primary publication:
The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels.
Mould J, Yasuda T, Schroeder CI, Beedle AM, Doering CJ, Zamponi GW, Adams DJ, Lewis RJ
J Biol Chem 279 34705-14 (2004)
PMID: 15166237

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134348 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Omega-conotoxin GVIA Chain: A
Molecule details ›
Chain: A
Length: 28 amino acids
Theoretical weight: 3.05 KDa
Source organism: Conus geographus
UniProt:
  • Canonical: P01522 (Residues: 46-72; Coverage: 53%)
Sequence domains: Conotoxin

Ligands and Environments

No bound ligands
1 modified residue:
Ligand HYP 3 x HYP

Experiments and Validation Details

Entry percentile scores
Refinement method: Solution structures were calculated using torsion angle dynamics/simulated annealing protocols

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Citations

16 review citations

Conus venom peptide pharmacology.
Lewis et al. (2012)
15 more

7 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
6 more