1tr4 Summary

pdbe.org/1tr4
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Solution structure of human oncogenic protein gankyrin

The structure was published by Yuan, C., Li, J., Mahajan, A., Poi, M.J., Byeon, I.J., and Tsai, M.D., in 2004 in a paper entitled "Solution structure of the human oncogenic protein gankyrin containing seven ankyrin repeats and analysis of its structure--function relationship." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of 26S proteasome non-ATPase regulatory subunit 10. This molecule has the UniProt identifier O75832 (PSD10_HUMAN)search. The sample contained 226 residues which is 100% of the natural sequence. Out of 226 residues 226 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 26S proteasome non-ATPase regulatory subunit 10 O75832 (1-226) (PSD10_HUMAN)search Homo sapienssearch 100% 226 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O75832 (1 - 226) 26S proteasome non-ATPase regulatory subunit 10 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (O75832) Ankyrin repeatsearch Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeatsearch PF00023: Ankyrin repeatsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (O75832) cytosolsearch nucleussearch cytoplasmsearch proteasome regulatory particle, base subcomplexsearch actin cytoskeletonsearch proteasome complexsearch nucleoplasmsearch proteasome regulatory particlesearch intermediate filament cytoskeletonsearch negative regulation of apoptotic processsearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch mRNA metabolic processsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch viral processsearch cellular nitrogen compound metabolic processsearch proteasome regulatory particle assemblysearch negative regulation of transcription from RNA polymerase II promotersearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch antigen processing and presentation of exogenous peptide antigen via MHC class Isearch antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentsearch RNA metabolic processsearch protein polyubiquitinationsearch mitotic cell cyclesearch regulation of apoptotic processsearch negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch negative regulation of DNA damage response, signal transduction by p53 class mediatorsearch gene expressionsearch positive regulation of protein ubiquitinationsearch negative regulation of release of cytochrome c from mitochondriasearch positive regulation of cell growthsearch apoptotic processsearch negative regulation of NF-kappaB transcription factor activitysearch negative regulation of MAPK cascadesearch positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch antigen processing and presentation of peptide antigen via MHC class Isearch small molecule metabolic processsearch regulation of cellular amino acid metabolic processsearch cytoplasmic sequestering of NF-kappaBsearch G1/S transition of mitotic cell cyclesearch positive regulation of cyclin-dependent protein kinase activitysearch protein bindingsearch transcription factor bindingsearch

Chain InterPro annotation
A Ankyrin repeatsearch Ankyrin repeat-containing domainsearch