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NMR structure of the human NOTCH-1 ligand binding region

The structure was published by Hambleton, S., Valeyev, N.V., Muranyi, A., et al., McMichael, A.J., Handford, P.A., and Downing, A.K., in 2004 in a paper entitled "Structural and functional properties of the human notch-1 ligand binding region" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Neurogenic locus notch homolog protein 1. This molecule has the UniProt identifier P46531 (NOTC1_HUMAN)search. The sample contained 116 residues which is < 90% of the natural sequence. Out of 116 residues 116 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Neurogenic locus notch homolog protein 1 P46531 (411-526) (NOTC1_HUMAN)search Homo sapienssearch < 90% 116 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P46531 (411 - 526) Neurogenic locus notch homolog protein 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A EGF-type modulesearch Lamininsearch EGF-like domainsearch, Calcium-binding EGF domainsearch

Chain ID Molecular function (GO)
A (P46531) calcium ion bindingsearch

Chain InterPro annotation
A EGF-type aspartate/asparagine hydroxylation sitesearch Epidermal growth factor-like domainsearch EGF-like calcium-binding domainsearch Insulin-like growth factor binding protein, N-terminalsearch EGF-like, conserved sitesearch EGF-like calcium-binding, conserved sitesearch