1tow Summary


Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand

The structure was published by Lehmann, F., Haile, S., Axen, E., et al., Lundback, T., Rondahl, L., and Barf, T., in 2004 in a paper entitled "Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Fatty acid-binding protein, adipocyte. This molecule has the UniProt identifier P15090 (FABP4_HUMAN)search. The sample contained 131 residues which is 99% of the natural sequence. Out of 131 residues 131 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Fatty acid-binding protein, adipocyte P15090 (2-132) (FABP4_HUMAN)search Homo sapienssearch 99% 131 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P15090 (2 - 132) Fatty acid-binding protein, adipocyte Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P15090) Fatty acid binding protein-likesearch Lipocalinsearch PF00061: Lipocalin / cytosolic fatty-acid binding protein familysearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P15090) white fat cell differentiationsearch transportsearch positive regulation of inflammatory responsesearch small molecule metabolic processsearch cytokine productionsearch brown fat cell differentiationsearch cellular response to lithium ionsearch negative regulation of transcription, DNA-templatedsearch triglyceride catabolic processsearch cholesterol homeostasissearch negative regulation of protein kinase activitysearch fatty acid bindingsearch lipid bindingsearch transporter activitysearch cytoplasmsearch nucleussearch extracellular vesicular exosomesearch lipid particlesearch

Chain InterPro annotation
A Cytosolic fatty-acid bindingsearch Lipocalin/cytosolic fatty-acid binding domainsearch Calycin-likesearch Calycinsearch