1tnf Summary

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THE STRUCTURE OF TUMOR NECROSIS FACTOR-ALPHA AT 2.6 ANGSTROMS RESOLUTION. IMPLICATIONS FOR RECEPTOR BINDING

The structure was published by Eck, M.J. and Sprang, S.R., in 1989 in a paper entitled "The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 1989.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of TUMOR NECROSIS FACTOR-ALPHA.

The molecule most likely forms homotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TUMOR NECROSIS FACTOR-ALPHA P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 96%
B TUMOR NECROSIS FACTOR-ALPHA P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 96%
C TUMOR NECROSIS FACTOR-ALPHA P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01375 (77 - 233) TUMOR NECROSIS FACTOR-ALPHA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C TNF-likesearch Jelly Rollssearch TNF(Tumour Necrosis Factor) familysearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B, C (P01375) tumor necrosis factor receptor bindingsearch membranesearch immune responsesearch

Chain InterPro annotation
A, B, C Tumour necrosis factor alphasearch Tumour necrosis factor domainsearch Tumour necrosis factorsearch Tumour necrosis factor-like domainsearch Tumour necrosis factor, conserved sitesearch