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PDBe Entry: 1tn7 
Protein Farnesyltransferase Complexed with a TC21 Peptide Substrate and a FPP Analog at 2.3A Resolution
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transferase
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X-RAY DIFFRACTION
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Resolution: 2.3 Å, R-factor: 18.0%, Free R-factor: 20.7%, Spacegroup: P 61
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02/11/2004, deposition: 11/06/2004, last revision: 24/02/2009
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Reid, T.S.; Terry, K.L.; Casey, P.J.; Beese, L.S.
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Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.
J.MOL.BIOL. vol:343, pag:417-433 (2004) [PubMed ID 15451670 ]
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FTase, farnesyltransferase, farnesyl transferase, prenyltransferase, CaaX, TC21, lipid modification, prenylation, substrate selectivity
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2.5.1.58 ExPASy BRENDA (A B), 2.5.1.59 ExPASy BRENDA (A)
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Rattus norvegicus(Norway rat) 10116(A B)
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Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (Ras proteins prenyltransferase alpha) (FTase-alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) Q04631 (A)
Protein farnesyltransferase subunit beta (EC 2.5.1.58) (FTase-beta) (CAAX farnesyltransferase subunit beta) (RAS proteins prenyltransferase beta) Q02293 (B)
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A, B, C
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1d8d, 1n4q, 1qbq, 1ft1, 1fpp, 1tn6, 1tn8, 1tnb, 1tno, 1tnu, 1tny, 1tnz
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| A |
Protein farnesyltransferase alpha subunit |
Protein |
Q04631 (FNTA_RAT)
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377 |
85% |
| B |
Protein farnesyltransferase beta subunit |
Protein |
Q02293 (FNTB_RAT)
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437 |
93% |
| C |
Fusion protein |
Protein |
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10 |
60% |
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| B |
ZINC ION |
ZN
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| B |
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID |
FII
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| B, A |
ACETIC ACID |
ACY
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