1ti6 Summary

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Crystal Structure of Pyrogallol-Phloroglucinol Transhydroxylase from Pelobacter acidigallici complexed with inhibitor 1,2,4,5-tetrahydroxy-benzene

The structure was published by Messerschmidt, A., Niessen, H., Abt, D., Einsle, O., Schink, B., and Kroneck, P.M.H., in 2004 in a paper entitled "Crystal structure of pyrogallol-phloroglucinol transhydroxylase, an Mo enzyme capable of intermolecular hydroxyl transfer between phenols" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Pyrogallol hydroxytransferase large subunit and Pyrogallol hydroxytransferase small subunit.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Pyrogallol hydroxytransferase large subunit P80563 (1-875) (PGTL_PELAC)search Pelobacter acidigallicisearch 100% 875 100%
C Pyrogallol hydroxytransferase large subunit P80563 (1-875) (PGTL_PELAC)search Pelobacter acidigallicisearch 100% 875 100%
E Pyrogallol hydroxytransferase large subunit P80563 (1-875) (PGTL_PELAC)search Pelobacter acidigallicisearch 100% 875 100%
G Pyrogallol hydroxytransferase large subunit P80563 (1-875) (PGTL_PELAC)search Pelobacter acidigallicisearch 100% 875 100%
I Pyrogallol hydroxytransferase large subunit P80563 (1-875) (PGTL_PELAC)search Pelobacter acidigallicisearch 100% 875 100%
K Pyrogallol hydroxytransferase large subunit P80563 (1-875) (PGTL_PELAC)search Pelobacter acidigallicisearch 100% 875 100%
B Pyrogallol hydroxytransferase small subunit P80564 (1-274) (PGTS_PELAC)search Pelobacter acidigallicisearch 100% 274 100%
D Pyrogallol hydroxytransferase small subunit P80564 (1-274) (PGTS_PELAC)search Pelobacter acidigallicisearch 100% 274 100%
F Pyrogallol hydroxytransferase small subunit P80564 (1-274) (PGTS_PELAC)search Pelobacter acidigallicisearch 100% 274 100%
H Pyrogallol hydroxytransferase small subunit P80564 (1-274) (PGTS_PELAC)search Pelobacter acidigallicisearch 100% 274 100%
J Pyrogallol hydroxytransferase small subunit P80564 (1-274) (PGTS_PELAC)search Pelobacter acidigallicisearch 100% 274 100%
L Pyrogallol hydroxytransferase small subunit P80564 (1-274) (PGTS_PELAC)search Pelobacter acidigallicisearch 100% 274 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P80563 (1 - 875) Pyrogallol hydroxytransferase large subunit Pelobacter acidigallici
P80564 (1 - 274) Pyrogallol hydroxytransferase small subunit Pelobacter acidigallici

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C, E, G, I, K (P80563) Formate dehydrogenase/DMSO reductase, C-terminal domainsearch, Formate dehydrogenase/DMSO reductase, domains 1-3search PF00384: Molybdopterin oxidoreductasesearch, PF01568: Molydopterin dinucleotide binding domainsearch
B, D, F, H, J, L (P80564) Cna protein B-type domainsearch, Ferredoxin domains from multidomain proteinssearch Alpha-Beta Plaitssearch, Immunoglobulinssearch PF05738: Cna protein B-type domainsearch, PF13247: 4Fe-4S dicluster domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, C, E, G, I, K (P80563) oxidation-reduction processsearch oxidoreductase activitysearch molybdenum ion bindingsearch metal ion bindingsearch pyrogallol hydroxytransferase activitysearch
B, D, F, H, J, L (P80564) oxidation-reduction processsearch iron-sulfur cluster bindingsearch pyrogallol hydroxytransferase activitysearch 4 iron, 4 sulfur cluster bindingsearch oxidoreductase activitysearch metal ion bindingsearch

Chain InterPro annotation
A, C, E, G, I, K Molybdopterin oxidoreductasesearch Molydopterin dinucleotide-binding domainsearch Aspartate decarboxylase-like domainsearch
B, D, F, H, J, L Collagen-binding surface protein Cna-like, B-type domainsearch Collagen-binding surface protein Cna, B-type domainsearch Immunoglobulin-like foldsearch 4Fe-4S ferredoxin-type, iron-sulphur binding domainsearch