1thk Summary

pdbe.org/1thk
spacer

Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II

The structure was published by Fisher, Z., Hernandez Prada, J.A., Tu, C.K., et al., Govindasamy, L., Silverman, D.N., and McKenna, R., in 2005 in a paper entitled "Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase II P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase II Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) lyase activitysearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch metal ion bindingsearch microvillussearch cytoplasmsearch plasma membranesearch cytosolsearch myelin sheathsearch extracellular vesicular exosomesearch axonsearch extracellular spacesearch basolateral plasma membranesearch apical part of cellsearch membranesearch bicarbonate transportsearch odontogenesis of dentin-containing toothsearch positive regulation of bone resorptionsearch response to pHsearch one-carbon metabolic processsearch angiotensin-activated signaling pathwaysearch regulation of intracellular pHsearch positive regulation of cellular pH reductionsearch response to steroid hormonesearch positive regulation of dipeptide transmembrane transportsearch response to zinc ionsearch morphogenesis of an epitheliumsearch positive regulation of osteoclast differentiationsearch response to organic substancesearch small molecule metabolic processsearch secretionsearch regulation of anion transportsearch kidney developmentsearch response to estrogensearch positive regulation of synaptic transmission, GABAergicsearch regulation of chloride transportsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch