1thb Summary

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REFINEMENT OF A PARTIALLY OXYGENATED T STATE HAEMOGLOBIN AT 1.5 ANGSTROMS RESOLUTION

The structure was published by Waller, D.A. and Liddington, R.C., in 1990 in a paper entitled "Refinement of a partially oxygenated T state human haemoglobin at 1.5 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 1990.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A (OXY) (ALPHA CHAIN) and HEMOGLOBIN A (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A (OXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN A (OXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN A (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A (OXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) oxygen bindingsearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch iron ion bindingsearch heme bindingsearch metal ion bindingsearch peroxidase activitysearch extracellular regionsearch membranesearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch blood microparticlesearch cytosolsearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch endocytic vesicle lumensearch small molecule metabolic processsearch oxygen transportsearch bicarbonate transportsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch transportsearch response to hydrogen peroxidesearch receptor-mediated endocytosissearch oxidation-reduction processsearch protein heterooligomerizationsearch
B, D (P68871) iron ion bindingsearch protein bindingsearch oxygen transporter activitysearch heme bindingsearch oxygen bindingsearch peroxidase activitysearch hemoglobin bindingsearch metal ion bindingsearch haptoglobin bindingsearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch cytosolsearch endocytic vesicle lumensearch blood microparticlesearch regulation of blood pressuresearch renal absorptionsearch regulation of blood vessel sizesearch transportsearch response to hydrogen peroxidesearch platelet aggregationsearch receptor-mediated endocytosissearch bicarbonate transportsearch protein heterooligomerizationsearch blood coagulationsearch oxygen transportsearch nitric oxide transportsearch oxidation-reduction processsearch positive regulation of cell deathsearch small molecule metabolic processsearch positive regulation of nitric oxide biosynthetic processsearch hydrogen peroxide catabolic processsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch