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EBI PDBe PDBeView

PDBe Entry: 1tg6 view

Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP
Summary
Header HYDROLASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.1 Å, R-factor: 28.0%, Free R-factor: 26.2%, Spacegroup: C 1 2 1
Released 22/03/2005, deposition: 28/05/2004, last revision: 24/02/2009
Authors Kang, S.G.search; Maurizi, M.R.search; Thompson, M.search; Mueser, T.search; Ahvazi, B.search
Primary citation Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP
J.STRUCT.BIOL.search vol:148, pag:338-352 (2004) [PubMed ID 15522782 ]search
Keywords mitochondrial ClpPsearch, Clp/Hsp 100search, X-ray crystallographysearch, ATP-dependent proteasesearch, HYDROLASEsearch
EC 3.4.21.92 ExPASy BRENDA search (A B C D E F G)
Organism Homo sapiens(human) 9606search(A B C D E F G)
UniProt Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial precursor (EC 3.4.21.92) (Endopeptidase Clp) Q16740search (A B C D E F G)
Solvent A, B, C, D, E, F, G
Related entries 1tyf
Polymers
Id Name Type UniProt Residues Observed
A, B, C, D, E, F, G Putative ATP-dependent Clp protease proteolytic subunit Protein Q16740 (CLPP_HUMAN)search
 277 70%
Heterogens
Id Name Ligands
A, B, D, E, F, G 1,4-DIETHYLENE DIOXIDE DIO search
A, B, C, D, F, G 1,2-ETHANEDIOL EDO search
D N-FORMYLMETHIONINE FME search
B, C, D, E, F GLYCEROL GOL search
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