1tg3 Summary

pdbe.org/1tg3
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Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II

The structure was published by Fisher, Z., Hernandez Prada, J.A., Tu, C.K., et al., Govindasamy, L., Silverman, D.N., and McKenna, R., in 2005 in a paper entitled "Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase II P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase II Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) carbonate dehydratase activitysearch zinc ion bindingsearch lyase activitysearch metal ion bindingsearch protein bindingsearch one-carbon metabolic processsearch bicarbonate transportsearch positive regulation of dipeptide transmembrane transportsearch response to zinc ionsearch carbon dioxide transportsearch regulation of intracellular pHsearch secretionsearch positive regulation of cellular pH reductionsearch positive regulation of osteoclast differentiationsearch odontogenesis of dentin-containing toothsearch response to organic substancesearch response to steroid hormonesearch response to estrogensearch response to pHsearch regulation of anion transportsearch morphogenesis of an epitheliumsearch angiotensin-activated signaling pathwaysearch small molecule metabolic processsearch kidney developmentsearch positive regulation of bone resorptionsearch cytoplasmsearch membranesearch cytosolsearch extracellular vesicular exosomesearch microvillussearch plasma membranesearch extracellular spacesearch apical part of cellsearch basolateral plasma membranesearch axonsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch